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猪流行性腹泻病毒分子生物学研究进展
引用本文:孙东波,冯力,时洪艳,陈建飞.猪流行性腹泻病毒分子生物学研究进展[J].动物医学进展,2006,27(10):11-14.
作者姓名:孙东波  冯力  时洪艳  陈建飞
作者单位:中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室猪传染病研究室,黑龙江哈尔滨,150001
摘    要:猪流行性腹泻病毒在Vero细胞上培养成功后,病毒全基因组的序列和分子结构特征,结构蛋白和非结构蛋白的生物学特性和功能,病原学、血清学和分子生物学的诊断技术,体液免疫、细胞免疫和局部黏膜免疫的机理,疫苗和病毒的细胞受体等方面得到了广泛的研究。但是,与其他冠状病毒相比,猪流行腹泻病毒的研究还比较滞后,许多研究还没有开展或不够深入,为了能加快对猪流行性腹泻病毒研究进程,对其最近的分子生物学研究进展做了综述,为猪流行性腹泻病毒的深入研究提供参考。

关 键 词:猪流行性腹泻病毒  分子生物学
文章编号:1007-5038(2006)10-0011-04
收稿时间:2006-07-11
修稿时间:2006年7月11日

Progress on Molecular Biology of Porcine epidemic diarrhea virus
SUN Dong-bo,FENG Li,SHI Hong-yan,CHEN Jian-fei.Progress on Molecular Biology of Porcine epidemic diarrhea virus[J].Progress In Veterinary Medicine,2006,27(10):11-14.
Authors:SUN Dong-bo  FENG Li  SHI Hong-yan  CHEN Jian-fei
Institution:Division of Swine Infectious Diseases, National Key Laboratory of Veterinary Biotechnology , Harbin Veterinary Research Institute, CAAS, Harbin, Heilongjiang,150001, China
Abstract:After Porcine epidemic diarrhea virus was successfully cultured in Vero cell,some progresses were obtained regarding entire genomic sequences and structural feature,biological property and function of structural and non-structural protein,diagnostic technique of etiology,serology and molecular biology,immune mechanism,vaccine and cell receptor of Porcine epidemic diarrhea virus.But research process of Porcine epidemic diarrhea virus fell behind other coronavirus members,many researches had not been done about Porcine epidemic diarrhea virus.To accelerate research course of Porcine epidemic diarrhea virus,progress of molecular biology of Porcine epidemic diarrhea virus was reviewed to serve as reference for advanced research of Porcine epidemic diarrhea virus.
Keywords:Porcine epidemic diarrhea virus  molecular biology
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