替米考星与泰乐菌素对畜禽常见病原菌抑菌作用比较

采用试管2倍稀释法对国产替米考星与泰乐菌素进行了畜禽常见的20种病原菌体外抑菌活性比较试验。结果表明,替米考星和泰乐菌素具有类似的抗菌谱,二者对革兰氏阳性菌均有良好的抑制作用。对革兰氏阴性菌二者除对禽多杀性巴氏杆菌、红斑丹毒丝菌、胸膜肺炎放线杆菌和鸡毒支原体均有较强的抑菌效果外,对其他菌则表现为抑菌效果较弱或抗药性。替米考星对部分病原菌如鸡白痢沙门菌、鼠伤寒沙门菌、肺炎克雷伯菌抑菌效果明显强于酒石酸泰乐菌素。总体来看,替米考星对畜禽常见病原菌的抑菌活性比泰乐菌素要强一些。

Comparison of Antibacter Effect of Tilmicosin with Tylosin on some Commonly Pathogenic Bacteria of Domestic Animals

The comparative activity against 20 commonly pathogenic bacteria of tilmicosin and tylosin was carried out with double dilution method in tubes.The results showed that tilmicosin has the similar antibacter activity with tylosin.They inhibited efficiently Gram-positive bacteria.For some Gram-negative bacteria,they inhibited efficiently Pasteurella aviseptica,Erysipelothrix rhusiopathiae,Actinobacillus pleuropneumoniae and Mycoplasma gallisepticum.But some other Gram-negative bacteria were less-susceptible or drug-fast.Some pathogenic bacteria such as Salmonella dysenteriae gallinarum,Salmonella typhimurium,Klebsiella pneumoniae were more susceptible to tilmicosin than to tylosin.As a whole,common pathogeny were more sensitive to tilmicosin than tylosin.