| 多潜能性维持因子Nanog研究进展 |
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| 引用本文： | 张运海,方富贵,利光辉,章孝荣.多潜能性维持因子Nanog研究进展[J].动物医学进展,2005,26(11):18-21. |
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| 作者姓名： | 张运海 方富贵 利光辉 章孝荣 |
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| 作者单位： | 安徽农业大学动物科技学院,安徽合肥,230036;安徽农业大学动物科技学院,安徽合肥,230036;安徽农业大学动物科技学院,安徽合肥,230036;安徽农业大学动物科技学院,安徽合肥,230036 |
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| 摘 要： |
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| 关 键 词： | Nanog 胚胎干细胞 白血病抑制因子 自我更新 多潜能性 |
| 文章编号： | 1007-5038（2005）11-0018-04 |
| 收稿时间： | 2005-08-19 |
| 修稿时间： | 2005年8月19日 |
Progress on Novel Pluripotency-Maintaining Factor Nanog |
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| ZHANG Yun-hai,FANG Fu-gui,LI Guang-hui,ZHANG Xiao-rong.Progress on Novel Pluripotency-Maintaining Factor Nanog[J].Progress In Veterinary Medicine,2005,26(11):18-21. |
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| Authors: | ZHANG Yun-hai FANG Fu-gui LI Guang-hui ZHANG Xiao-rong |
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| Institution: | College of Animal Science and Technology, Anhui Agricultural University, Hefei,Anhui, 230036, China |
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| Abstract: | Embryonic stem cells(ES) can undergo extended proliferation lifespan while keep the ability of multilineage differentiation.These characteristics enable ES cell to be of great potential applications in medicine,agriculture and basic research,especially in developing novel therapy for some human diseases.It is reported that leukemia inhibitory factor(LIF) can maintain the self-renewal ability of mouse ES cell through activating Stat3.However,interestingly,LIF/Stat3 is dispensable for maintenance of ICM and human ES cell,which suggest that there might exist another path.Recently a new pluripotency-maintaining factor called Nanog was found.Nanog alone can support the self-renewal of ES cell bypassing the LIF/Stat3 pathway.The present paper reviewed mainly the discovery of Nanog,its characteristic of genome sequence and expression of coding gene-Nanog. |
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| Keywords: | Nanog |
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