骨质疏松动物模型研究进展

骨质疏松动物模型是骨质疏松症实验研究中不可缺少的研究材料。动物模型的病因、发病机理、病理变化及症状应尽量与临床接近。去卵巢动物模型是目前最常用的绝经后骨质疏松动物模型,且与临床绝经后骨质疏松症比较相似。SAMP6 小鼠是仅有的一种能证明增龄性骨脆性骨折的实验动物,是研究老年性骨质疏松症的较实用的动物模型。睾丸切除鼠骨质疏松动物模型是研究男性骨质疏松症的重要工具。内分泌代谢性、营养缺乏性、药物性、废用性骨质疏松等继发性骨质疏松动物模型常根据其原发病的情况制作,其病理变化与临床接近。研究者应根据自己的研究范围,选择合适的动物模型。

Recent Situation of Osteoporosis Animal Model Research

Osteoporosis(OP) animal model is an indispensable mean in the experimental research of OP. The nosogenesis, pathogenesis, pathologic transformation, symptom and physical sign of the model should be similar to the condition of a clinical patient.Bilateral ovariectomized animal model(OVX) is the most frequently used postmenopaused osteoporosis(PSOP) animal model. SAMP6 mice has been verified to be the only experimental animal which risk of fracture increase with ageing and a practical model of senile osteoporosis(SOP). ORX animal model is an important mean in the research of male osteoporosis(MOP). Animal model of second osteoporosis such as OP of endocrine metablic, deficiency, disuse and medicamentosa,are often made on the basis of the condition of their primary disease or that of the direct cause of OP. Researchers should select appropriate animal model according to their research field.