牛传染性鼻气管炎病毒致病机制研究进展

牛传染性鼻气管炎病毒(IBRV)主要引起牛的呼吸道、生殖道等炎症反应,也可以引起呼吸困难及流产。IBRV的致病机制尚不清楚,目前发现IBRV的非结构蛋白和结构糖蛋白与病毒毒力相关,不但影响病毒的复制及对宿主细胞的感染,同时也与病毒的免疫逃逸密切相关。除此之外,IBRV通过诱导宿主细胞凋亡造成持续性感染及激活炎症复合体诱导严重的炎症反应,造成宿主广泛病理反应的发生。因此,探索IBRV毒力蛋白结构功能、IBRV感染诱导的细胞凋亡及宿主炎性复合体激活的分子机制,将成为未来IBRV研究的热点。

Progress on Pathogenetic Mechanism of Infectious Bovine Rhinotracheitis Virus

Infectious bovine rhinotracheitis (IBR) is caused by infectious bovine rhinotracheitis virus (IBRV) with the characteristic of severe inflammation,expiratory dyspnea and abortion in bovine,and is pandemic around the world and causing enormous economic losses.However,there is no available research for the pathogenetic mechanism of IBRV.Yet viral structural or non-structural proteins are associated with its virulence that have effect on IBRV replication,infection and immune escape.Moreover, IBRV can induce apoptosis on host cells, and can result in serious inflammatory response by activation of inflammasome, which can lead to persistent infection of IBRV and extensive pathophysiological process.Therefore, the exploration of structure and function of IBRV virulent protein(s), the mechanism of apoptosis induction and activation of inflammasome on infected host cells would be the focus on in the IBRV research area in the future.