| 喹乙醇及其主要代谢物在罗非鱼体内的药物动力学研究 |
| |
| 引用本文： | 陈永平,林黎明,张素青,李春青,李兆千.喹乙醇及其主要代谢物在罗非鱼体内的药物动力学研究[J].动物医学进展,2011(10):54-58. |
| |
| 作者姓名： | 陈永平 林黎明 张素青 李春青 李兆千 |
| |
| 作者单位： | 农业部渔业环境及水产品质量监督检验测试中心;山东省出入境检验检疫技术中心; |
| |
| 摘 要： | 采用高效液相色谱-质谱法,研究肌肉注射给药方式下,喹乙醇及其代谢物在罗非鱼(Tilapiafish)体内的药物代谢动力学.罗非鱼注射给药20 mg/kg后,其血浆、肌肉、肝脏中药物浓度-时间曲线关系符合一级吸收的二室开放动力学模型.喹乙醇在罗非鱼体内消除较快,在血液、肌肉、肝脏中的消除半衰期(t 1/2β)分别为5.2...
|
| 关 键 词： | 喹乙醇 喹乙醇代谢物 药代动力学 罗非鱼 |
Pharmacokinetics of Olaquindox and Its Metabolite in Tilapia Fish |
| |
| CHEN Yong-ping,LIN Li-ming,ZHANG Su-qing,LI Chun-qing,LI Zhao-qian.Pharmacokinetics of Olaquindox and Its Metabolite in Tilapia Fish[J].Progress In Veterinary Medicine,2011(10):54-58. |
| |
| Authors: | CHEN Yong-ping LIN Li-ming ZHANG Su-qing LI Chun-qing LI Zhao-qian |
| |
| Institution: | CHEN Yong-ping1,LIN Li-ming2,ZHANG Su-qing1,LI Chun-qing1,LI Zhao-qian1(1.Supervision and Test Center for Fisheries Environment and Quality of Fishery Products of Ministry Agriculture,Tianjin,300221,China,2.The Technical Center of Shandong Entry-exit Inspection and Quarantine Bureau,Qingdao,Shandong,26600,China) |
| |
| Abstract: | The pharmacokinetics,tissue metabolism and elimination of olaquindox(OQX) and its metabolite methyl-3-quinoxaline-2-carboxylic acid(MQCA) were investigated in Tilapia fish,after administration by single intramuscular injection of 20 mg/kg.Plasma and tissue concentrations of olaquindox and its metabolite MQCA were simultaneously determined by a high performance liquid chromatography-tandem mass spectrometric(LC-MS/MS) method.The concentrations versus time in plasma,muscle and liver from the Tilapia fish were... |
| |
| Keywords: | olaquindox methyl-3-quin0xaline-2-carboxylic acid pharmacokinetics Tilapia fish |
| 本文献已被 CNKI 等数据库收录！ |
|
