| RNA干扰抑制口蹄疫病毒复制研究进展 |
| |
| 引用本文： | 徐娜,刘明,李宝玉,柳纪省.RNA干扰抑制口蹄疫病毒复制研究进展[J].动物医学进展,2010,31(3):82-86. |
| |
| 作者姓名： | 徐娜 刘明 李宝玉 柳纪省 |
| |
| 作者单位： | 中国农业科学院兰州兽医研究所传染病室,家畜疫病病原生物学国家重点实验室,农业部兽医公共卫生重点开放实验室,甘肃兰州,730046 |
| |
| 摘 要： | 鉴于现有疫苗和抗病毒药物在治疗口蹄疫方面存在的局限性,寻找新型抗病毒策略势在必行,而RNA干扰正是一种有益的尝试。RNA干扰通过沉默哺乳动物细胞中的基因表达,可有效的阻断口蹄疫病毒在宿主体内的复制。论文以口蹄疫病毒引起宿主细胞病变、RNA干扰的机制及RNA干扰抑制FMDV在宿主细胞内复制为内容,探讨如何更加有效地防控口蹄疫。
|
| 关 键 词： | 口蹄疫病毒 RNA干扰 抑制 病毒复制 |
Progress on RNA Interference in Inhibition of the Foot-and-mouth Disease Virus Replication |
| |
| XU Na,LIU Ming,LI Bao-yu,LIU Ji-xing.Progress on RNA Interference in Inhibition of the Foot-and-mouth Disease Virus Replication[J].Progress In Veterinary Medicine,2010,31(3):82-86. |
| |
| Authors: | XU Na LIU Ming LI Bao-yu LIU Ji-xing |
| |
| Institution: | Animal Infectious Diseases Research Laboratory;Lanzhou Veterinary Research Institute;Chinese Academy of Agricultural Sciences;State Key Laboratory of Veterinary Etiological Biology;Key Laboratory of Veterinary Public Health of Ministry of Agriculture;Lanzhou;Gansu;730046;China |
| |
| Abstract: | Because of the limited effectiveness of existing vaccines and antiviral drugs in treat of foot-and-mouth disease(FMD),it is necessary to find a new strategy to control the virus,therefore RNA interference(RNAi)is a kind of beneficial attempt.RNAi is an effective means of suppressing foot-and-mouth disease virus(FMDV)replication in vitro,through the silence of specific viral gene expression in mammalian cells.This paper reviewed the host cell cytopathic effect caused by FMDV,the mechanism of RNA interference... |
| |
| Keywords: | Foot-and-mouth disease virus RNA interference inhibiton virus replication |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
