Pinpointing the candidate region for muscular dystrophy in chickens with an abnormal muscle gene |
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| Authors: | Hirokazu MATSUMOTO Hideaki MARUSE Kanako YOSHIZAWA Shinji SASAZAKI Akira FUJIWARA Takeki KIKUCHI Nobutsune ICHIHARA Fumio MUKAI Hideyuki MANNEN |
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| Institution: | Graduate School of Science and Technology, Kobe University, Nada, Kobe,;Laboratory Animal Research Station, Nippon Institute for Biological Science, Kobuchisawa,;Department of Animal Models for Human Disease, National Institute of Neuroscience, NCNP, Kodaira, Tokyo,;Department of Anatomy I, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa,;Laboratory of Animal, Faculty of Agriculture, Kobe University, Nada, Kobe, Japan |
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| Abstract: | Muscular dystrophies, a group of inherited diseases with the progressive weakness and degeneration of skeletal muscle, contain genetically variable diseases. Though chicken muscular dystrophy with abnormal muscle (AM) has long been known, the gene responsible has not yet been identified. In this study, a resource family for AM was established with 487 F2 individuals and 22 gene markers, including microsatellite and insertion–deletion markers, were developed. The haplotypes were analyzed with these markers for the candidate region of GGA2q described in a previous study. The candidate region was successfully narrowed down to approximately 1Mbp. The region included seven functional genes predicted as the most likely AM candidates. |
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| Keywords: | chicken haplotype analysis microsatellite muscular dystrophy |
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