Calcium metabolism of pregnant rats fed a vitamin D-depleted diet |
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| Authors: | Yamagishi Norio Sassa Hiromi Sato Reeko Taniguchi Kazuyuki Okura Norimoto Sato Shigeru Naito Yoshihisa |
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| Institution: | Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan. |
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| Abstract: | The effects of vitamin D (VD) deficiency on calcium (Ca) metabolism during pregnancy were evaluated in rats fed VD-repleted (VD-repleted rats) and VD-depleted (VD-depleted rats) diets. In the VD-depleted rats, the plasma concentrations of 1,25-dihydroxyvitamin D and Ca decreased severely, whereas the parathyroid hormone concentrations increased. The Ca contents of the feces of the VD-depleted rats were higher than those of the VD-repleted rats. The fetal Ca contents of the VD-repleted and VD-depleted rats increased continuously, but that of the VD-depleted rats was lower. These data reveal that VD deficiency during pregnancy induces severe hypocalcemia due to reduced intestinal absorption of Ca and elevated fetal demand for Ca. |
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