罗格列酮对异育银鲫血清生化指标和糖代谢的影响

研究罗格列酮对异育银鲫血清生化指标和糖代谢指标的影响。选取480尾初始体重(5.30±0.38)g的异育银鲫,随机分为4个组,每组4个重复,每个重复30尾鱼。对照组饲喂基础日粮,试验Ⅰ组、试验Ⅱ组、试验Ⅲ组在基础日粮基础上分别添加10、15 mg/kg和20 mg/kg罗格列酮,试验期为30 d。结果表明:与对照组相比,试验Ⅱ组和试验Ⅲ组血清中的谷丙转氨酶(GPT)活性显著升高(P<0.05);Ⅲ组血清中的谷草转氨酶(GOT)和乳酸脱氢酶(LDH)活性显著升高(P<0.05);各试验组血清中的总蛋白(TP)含量均显著增加(P<0.05),血糖浓度和胰岛素水平显著降低(P<0.05),肌糖原含量显著增加(P<0.05)。结果说明,日粮中添加10、15 mg/kg和2 0 mg/kg的罗格列酮均能够显著降低血糖的浓度,添加水平为10 mg/kg对异育银鲫肝胰脏无损伤。

Effects of rosiglitazone on serum biochemical indices and glucose metabolism in Carassius auratus gibelio

The experiment was conducted to study the effects of dietary rosiglitazone on serum biochemical indices and glucose metabolism of Carassius auratus gibelio.Four hundred and eighty Carassius auratus gibelio with(5.30±0.38)g body weight were randomly selected to 4 groups with 4 replicates of 30 each.The control group was fed with the basal diet,while trail group Ⅰ,Ⅱand Ⅲwere fed with the basal diet added with 10,15 mg/kg and 20 mg/kg rosiglitazone respectively.The results showed that compared with the control group,activity of GPT in serum was increased significantly in group Ⅱand Ⅲ(P < 0.05);activity of GOT and LDH in serum was increased significantly in group Ⅲ(P < 0.05);content of TP in serum was increased significantly in every trial group(P < 0.05);level of blood glucose and insulin in serum was decreased significantly in every trial group(P < 0.05);the content of muscle glycogen was increased significantly in every trial group(P < 0.05).In conclusion,adding three levels of rosiglitazone to diet could significantly decrease the level of blood glucose of Carassius auratus gibelio.In this experiment,the optimum adding levels was 10 mg/kg,which had no damage to liver and pancreas.