SLOW RELEASE CISPLATIN COMBINED WITH RADIATION FOR THE TREATMENT OF CANINE NASAL TUMORS |
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Authors: | Susan E Lana DVM William S Dernell DVM MS Susan M Larue DVM MS PhD Mary J Lafferty Evan B Douple PhD John H Brekke DDS Stephen J Withrow DVM |
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Institution: | Comparative Oncology Unit, Department of Clinical Sciences;Department of Radiological Health Sciences, College of Veterinary Medicine and Biological Sciences, Colorado State University, Ft. Collins, CO;Department of Medicine, Dartmouth Medical School, Lebanon, NH;Department of Medicine, THM Biomedical, Duluth, MN |
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Abstract: | Thirteen dogs with malignant tumors of the nasal cavity were treated with a combination of slow release cisplatin and megavoltage radiation. Radiation was delivered on a Monday through Friday schedule using a 6 MV linear accelerator. The median total dose was 49.5 Gy (range 49.5-56 Gy). Cisplatin was given using an open-cell polylactic acid polymer, impregnated with the drug and implanted intramus-cularly at a distant site, as a slow release delivery system (OPLAn-Pt THM Biomedical, Inc]). The median dose used was 60 mg/m2 (range 60–100 mg/m2). When combined with radiation, this delivery system caused no systemic drug toxicity, and a local tissue reaction was seen in only two dogs. Acute side effects to normal tissue from radiation were not enhanced, as measured by subjective assessment. When compared to a group of historical controls that received radiation without OPLA-Pt, the dogs that received combined radiation and cisplatin had longer overall survival times, with a median of 580 days. The control group had a median survival of 325 days. Previously reported median survival times for comparable megavoltage radiation treatment range from 6 to 13 months. Some dogs in both groups also received adjubant chemotherapy but this did not influence survival time. By multivariate analysis, only the use of OPLA-Pt was found to significantly influence survival, with a p value of p = 0.023. Mega-voltage radiation and slow release cisplatin appears to be a well tolerated combination that may favorably affect survival of dogs with nasal tumors. |
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Keywords: | canine nasal tumors megavoltage radiation slow release cisplatin radiopotentiation |
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