| 鸭源新城疫病毒强毒株对鸭的致病性 |
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| 引用本文： | 刘梅,程旭,沈欣悦,周生,韦玉勇,刘加圣,戴亚斌.鸭源新城疫病毒强毒株对鸭的致病性[J].兽医大学学报,2014(2):214-218,226. |
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| 作者姓名： | 刘梅 程旭 沈欣悦 周生 韦玉勇 刘加圣 戴亚斌 |
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| 作者单位： | 中国农业科学院家禽研究所,江苏扬州225125 |
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| 基金项目： | 国家公益性行业（农业）科研专项经费资助项目（201003012）;国家高技术研究发展计划（“863”计划）资助项目（2011AAl0A209）;江苏省农业三新工程资助项目（SX[2011]l78） |
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| 摘 要： | 对鸭源新城疫病毒（NDV）强毒株JSD0812对鸭的致病性进行了研究。结果显示，对于15日龄雏鸭，JSD0812株病毒尿囊液的半数致死剂量（LD50）为101mL。15，30，45，60。110日龄鸭肌肉注射感染试验结果表明，所有日龄鸭感染JSD0812株后均可发病，但死亡率随日龄的增长而下降，110日龄鸭感染后未见死亡。鸭感染后可经咽喉和/或泄殖腔短期排毒，感染鸭组织器官中病毒分离率较低。
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| 关 键 词： | 鸭 新城疫病毒 致病性 半数致死量 排毒 分布 |
Pathogenicity of duck origin virulent Newcastle disease virus strain in ducks |
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| Authors: | L U Mei CHENG Xu SHEN Xin-yue ZHOU Sheng WEI Yu-yong LIU Jia-sheng DAI Ya-bin |
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| Institution: | ＂ ( Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, J ia ngsu 2 2 512 5, China ) |
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| Abstract: | The pathogenicity of duck origin Newcastle disease virus （NDV） JSD0812 strain in ducks was investigated in this study. The median lethal dose （LD50） of virus-containing allantoic fluid in 15-day old ducklings was 10 /0. 1 mL. Experimental infections via intramuscular injection of 15,30,45,60, and 110 days old ducks showed that all infected ducks displayed overt clinical signs, but the mortality had a decreased tendency with increasing age,and no 110-day-old ducks died after infection. The infected ducks excreted infectious virus from the pharynx and/or cloaca for short pe- riods. The percentage of virus isolation in tissues was generally low, even in those from died ducks. |
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| Keywords: | duck Newcastle disease virus pathogenicity median lethal dose virus shedding distribution |
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