| 氯化汞对SD大鼠脑组织氧化损伤的影响 |
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| 引用本文： | 路浩,张浩,赵宝玉,韦冬梅,宋岩岩.氯化汞对SD大鼠脑组织氧化损伤的影响[J].兽医大学学报,2012(1):122-124. |
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| 作者姓名： | 路浩 张浩 赵宝玉 韦冬梅 宋岩岩 |
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| 作者单位： | 西北农林科技大学动物医学院,陕西杨凌712100 |
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| 基金项目： | 基金项目：教育都高校博士点基金项目（20100204120018）;西北农林科技大学人才基金资助项目（Z111020828） |
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| 摘 要： | 24只SD大鼠被随机均分为4组，即C组为对照组（饮用蒸馏水），L组为汞低剂量组（50mg／L），M组为汞中剂量组（100mg／L），H组为汞高剂量组（200mg／L），采用自由饮水染毒，染毒时间为21d。采用半自动生化分析仪测定汞对SD大鼠脑组织谷胱甘肽过氧化物酶（GSH—Px）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性及总抗氧化能力（T—AOc）和丙二醛（MDA）含量的影响。结果显示，与对照组比较，各染毒纽GSH—Px、SOD和CAT活性及T—AOC均呈下降趋势，部分参数差异显著（P〈0．05），而MDA含量则显著升高（P〈0．05）。结果表明，低刘量汞暴露对SD大鼠脑组织主要抗氧化酶活性有明显抑制作用，显著降低动物机体的抗氧化能力。
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| 关 键 词： | 氯化汞 SD大鼠 氧化损伤 |
Effect of mercuric chloride on oxidative damage of brain tissues in SD rats |
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| Authors: | LU Hao ZHANG Hao ZHAO Bao-yu WEI Dong-mei SONG Yan-yan |
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| Institution: | (College of Veterinary Medicine, Northwest A ＆ F University ,Yangling , Shaanxi 712100, China) |
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| Abstract: | In order to observe the effects of mercuric chloride to oxidative damage of brain at low doses in SD rats, 24 SD rats were separated into control group,low （50 mg/L） ,middle （100 mg/L） and high dose （200 mg/L） groups of mercury,which were given in the drinking water. After successively exposed for 21 days, GSH-Px, SOD, CAT, T AOC and MDA in brain tissues were analyzed by semi-automatic biochemical analyzer, respectively. The results showed a decrease of GSH-Px, SOD, CAT and T-AOC in each poisoning groups, wich significant difference among part groups （P〈0.05） ,while significant increase of MDA （P〈0.05）. This study suggests mercuric chloride of lowdoses would have a marked inhibitory effect on antioxidase of brain tissues,and significantly reduce oxidation resist ance in SD rats. |
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| Keywords: | mercuric chloride SD rats oxidative damage |
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