| 鸡食管扁桃体中T、B淋巴细胞的发育及其定位分布 |
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| 引用本文： | 栾维民,杨树宝,张英楠,史明,冯小刚.鸡食管扁桃体中T、B淋巴细胞的发育及其定位分布[J].中国预防兽医学报,2011,33(3). |
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| 作者姓名： | 栾维民 杨树宝 张英楠 史明 冯小刚 |
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| 作者单位： | 1. 吉林农业大学动物科学技术学院,吉林长春,130118
2. 吉林农业大学发展学院,吉林长春,130600 |
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| 基金项目： | 国家自然科学基金资助项目(30771557) |
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| 摘 要： | 为研究T淋巴细胞和B淋巴细胞在鸡食管扁桃体中的出现、迁移、组织定位分布以及数量变化规律等一系列发育过程,本研究通过免疫组织化学方法,应用CD3和IgA单克隆抗体,研究鸡食管扁桃体的组织结构发育过程和淋巴细胞的发育过程。结果显示,各时期T、B淋巴细胞主要分布在两个部位:隐窝固有层和皱襞固有层,尤其是在隐窝固有层中T、B淋巴细胞较多;随着日龄增长,食管扁桃体中T、B淋巴细胞数量逐渐增多,并在35日龄时达到稳定;许多粘液腺周围形成淋巴聚集物,并突入腺腔,粘液腺上皮转化为淋巴上皮;21日龄之后,B淋巴细胞以IgA+细胞为主,数量超过CD3+细胞。研究表明,随着年龄增长,鸡食管扁桃体的免疫功能逐渐增强,并在21日龄之前以细胞免疫为主,21日龄之后以IgA介导的粘膜免疫为主。
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| 关 键 词： | 食管扁桃体 淋巴细胞 发育 定位分布 |
Development and distribution of T and B lymphocytes in oesophageal tonsils of chicken |
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| LUAN Wei-min,YANG Shu-bao,ZHANG Ying-nan,SHI Ming,FENG Xiao-gang.Development and distribution of T and B lymphocytes in oesophageal tonsils of chicken[J].Chinese Journal of Preventive Veterinary Medicine,2011,33(3). |
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| Authors: | LUAN Wei-min YANG Shu-bao ZHANG Ying-nan SHI Ming FENG Xiao-gang |
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| Institution: | LUAN Wei-min1,YANG Shu-bao1,ZHANG Ying-nan2,SHI Ming1,FENG Xiao-gang1(1.College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China,2.College of development,Changchun 130600,China) |
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| Abstract: | The occurrence,migration,tissue localization and quantity changes of T,B lymphocytes in chicken oesophageal tonsils were examined using the CD3 and IgA monoclonal antibodies by immunohistochemical method.The findings showed that T,B lymphocytes mainly distributed in two positions:lamina propria of crypt and lamina propria of folds,particularly more in lamina propria of crypt;T and B lymphocytes kept increasing with the increase of age,and stable by 35-day-old;Many lymph aggregates formed around cryptae muco... |
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| Keywords: | oesophageal tonsils lymphocytes development localization |
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