ORIGINAL ARTICLE: Inulin‐coated butyrate increases ileal MCT1 expression and affects mucosal morphology in the porcine ileum by reduced apoptosis |
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| Authors: | M Lacorn M Goerke R Claus |
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| Institution: | 1. R‐Biopharm, Darmstadt, Germany;2. Fachgebiet Futtermittelkunde, Institut für Tierern?hrung, Universit?t Hohenheim, Stuttgart, Germany;3. Fachgebiet Tierhaltung und Leistungsphysiologie, Institut für Tierhaltung und Tierzüchtung, Universit?t Hohenheim, Stuttgart, Germany |
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| Abstract: | Carbohydrates, which were not digested in the jejunum, will be fermented by micro‐organisms to short chain fatty acids. These are transported by the monocarboxylate transporter 1 (MCT1) through the gut wall and serve as fuels for colonic cells. To deliver butyrate to the distal part of the intestine, inulin with a low precaecal digestibility was chosen as a coating material. Approximately 150 g of inulin‐coated butyrate (containing 81 g butyrate) per day was fed to pigs (mean weight: 97 kg) over a period of 6 days after an adaptation period of 6 days with linear increasing amounts of butyrate. The following observations compared to controls were observed: (1) coating was digested microbially in the ileum; (2) MCT1‐mRNA showed a higher expression in the ileum; (3) apoptosis was reduced in the ileum but mitosis was not changed; and (4) length of villi increased by approximately 25% in the ileum. Feeding inulin‐coated butyrate resulted in an increased ileal surface. Delivery of butyrate to the colon requires a more resistant inulin‐coating. |
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| Keywords: | apoptosis butyrate intestine inulin coating MCT1 morphology pig |
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