不同剂量氟苯尼考对猪血液生化指标及猪瘟抗体的影响

40头70日龄健康猪随机分为高、中、低剂量组和对照组,每组10头,各试验组注射猪瘟弱毒疫苗(2头份/猪),同时高、中、低剂量组分别按每千克体质量于饲料中加入120、60、30 mg氟苯尼考,连续给药7 d,停药后1、8、15、22、29 d,对相关的血液生化指标以及猪瘟抗体水平进行检测分析.结果表明,停药后1、8 d,所有氟苯尼考添加组的猪瘟抗体滴度下降,仅120 mg/kg组差异显著(P<0.05),停药15 d后抗体水平恢复至正常水平;60和120mg/kg给药组TP含量在停药后1、8 d均显著下降(P<0.05);所有给药组的ALT活性在所有检测时间内均显著上升(P<0.05或P<0.01);所有给药组的γGT活性在停药后1 d均显著上升(P<0.05),而60和120 mg/kg组γGT在第8天仍显著上升(P<0.05);所有给药组的BUN含量在停药后1 d均显著升高(P<0.05或P<0.01);AST、LDH、CHE活性和ALB、CRE含量与对照组相比无显著差异(P>0.05);表明每千克体质量60 mg以上氟苯尼考在饲料中饲喂7 d后,对部分生化指标有一定的影响,应引起重视.

The impact of different dose florfenicol on blood biochemical indexes in pigs and antibody against classical swine fever virus

Forty 70-day-old healthy pigs were randomly divided into high-dose group,moderate-dose group,low-dose group and the control group of 10 pigs each which received 2 doses vaccine against classical swine fever virus and were feed 120.60 and 30 mg florfenicol per kg body weight in feedstuff for 7 d,respectively.At 1,8,15,22,29 d post administration,hematology analysis and the detection of antibody aganist classical swine fever virus were carried out.In comparision with the control group,the antibody levels of all drug-added groups decreased at 1 and 8 d post administration,especially in 120 mg/kg group(P<0.05)and the antibody titres recovered at 15 d post administration.The contents of TP in 60 mg/kg and 120 mg/kg groups were decreased singnificantly at 1 and 8 d post administration(P<0.05).The activity of ALT was significantly increased in all drug-added groups(P<0.05 or P<0.01).The activity of γGT in all drug-added groups increased significantly at 1 day post administration(P<0.05),and until to 8 day post administration in 60 mg/kg and 120 mg/kg groups(P<0.05).The content of BUN was significantly increased in all drug-added groups(P<0.05 or P<0.01).In comparision with the control,there was no obvious change on the acitivities of AST,LDH,CHE and the contents of ALB,CRE(P>0.05).The results indicated that some biochemical indexes of pigs were affected with above 60 mg florfenicol per kg body weight in feedstuff for 7 d.