| 布鲁菌介导细胞自噬的研究进展 |
| |
| 引用本文： | 顾国婧,李博文,李文杰,周志雄,罗艺晨,帅学宏,赵宇,陈吉轩,黄庆洲,伍莉,焦寒伟.布鲁菌介导细胞自噬的研究进展[J].中国兽医学报,2021(2):381-387. |
| |
| 作者姓名： | 顾国婧 李博文 李文杰 周志雄 罗艺晨 帅学宏 赵宇 陈吉轩 黄庆洲 伍莉 焦寒伟 |
| |
| 作者单位： | ;1.西南大学动物科学学院医学研究院免疫学研究中心/兽医科学工程研究中心 |
| |
| 基金项目： | 国家自然科学基金资助项目(31802215);重庆市基础研究与前沿探索计划资助项目(cstc2018jcyjA0807,cstc2020jcyj-msxm0522);中央高校基本科研业务费资助项目(XDJK2020C022,XDJK2019C024)。 |
| |
| 摘 要： | 布鲁菌是布鲁菌病的病原体,在世界范围内给养殖业带来巨大损失。自噬是细胞的一种代谢方式,细胞在自噬相关基因的调控下清除细胞内病原微生物和吞噬降解受损、衰老细胞器及大分子物质,以维持机体内环境平衡。布鲁菌入侵细胞后,能够诱发细胞自噬,而这一复杂的过程需要很多细胞因子的参与,探究布鲁菌引发的细胞自噬已成为揭示布鲁菌致病机制的新热点,现就这一新热点的研究进展进行综述。
|
| 关 键 词： | 布鲁菌病 布鲁菌 细胞自噬 致病机制 毒力因子 |
Progress in the study on Brucella-mediated autophagy |
| |
| GU Guojing,LI Bowen,LI Wenjie,ZHOU Zhixiong,LUO Yichen,SHUAI Xuehong,ZHAO Yu,CHEN Jixuan,HUANG Qingzhou,WU Li,JIAO Hanwei.Progress in the study on Brucella-mediated autophagy[J].Chinese Journal of Veterinary Science,2021(2):381-387. |
| |
| Authors: | GU Guojing LI Bowen LI Wenjie ZHOU Zhixiong LUO Yichen SHUAI Xuehong ZHAO Yu CHEN Jixuan HUANG Qingzhou WU Li JIAO Hanwei |
| |
| Institution: | (Immunology Research Center of Medicine Institute/Veterinary Scientific Engineering Research Center,College of Animal Science,Southwest University,Chongqing 402460,China) |
| |
| Abstract: | Brucella is a Gram-negative bacterium.As the pathogen of brucellosis,it leads to great losses to the breeding industry worldwide.Autophagy is a cell metabolic mode.Under the regulation of autophagy-related genes,cells scavenge intracellular pathogenic microorganisms or phagocytize and degrade damaged or senescent organelles and macromolecules substances to maintain the balance of the intracellular environment.Brucella invades cells,which can induce the occurrence of autophagy,and a lot of cytokines involve in this complex process.Exploring the autophagy induced by Brucella has become a new hot spot to reveal the pathogenesis of Brucella.This paper makes a research progress on this new hot spot. |
| |
| Keywords: | Brucellosis Brucella autophagy pathogenic mechanism virulence factor |
| 本文献已被 维普 等数据库收录！ |
|
