| 长效盐酸多西环素注射液在猪体内残留的消除规律 |
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| 引用本文： | 李媚,刘伟坚,黄显会,曾振灵.长效盐酸多西环素注射液在猪体内残留的消除规律[J].中国兽医学报,2011,31(2). |
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| 作者姓名： | 李媚 刘伟坚 黄显会 曾振灵 |
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| 作者单位： | 华南农业大学,兽医学院,广东,广州,510642 |
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| 基金项目： | 国家“十一五”科技支撑重点项目(2006BAD31B06) |
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| 摘 要： | 在常规饲养条件下,对35头健康成年猪按10 mg/kg体质量的剂量肌肉注射10%长效盐酸多西环素注射液,给药2次,给药间隔时间为48 h。第2次给药后12 h及2、5、9、14、192、5 d分别屠宰5头猪,分别采取每头猪的肌肉、肝脏、肾脏、皮肤+脂肪和注射位点肌肉等5种组织,用高效液相色谱法进行残留量测定。结果表明:在第2次给药后19 d,多西环素在各组织均能检测到,且残留均低于残留限量。多西环素残留浓度大小顺序:注射部位(肾脏(肝脏(皮脂(肌肉。采用WT1.4软件制定的统计方法来处理猪组织中药物浓度-时间数据,以制定休药期。
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| 关 键 词： | 多西环素 猪组织 残留 休药期 高效液相色谱 |
Residual elimination of long-acting doxycycline hydrochloride injection in swines |
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| LI Mei,LIU Wei-jian,HUANG Xian-hui,ZENG Zhen-ling.Residual elimination of long-acting doxycycline hydrochloride injection in swines[J].Chinese Journal of Veterinary Science,2011,31(2). |
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| Authors: | LI Mei LIU Wei-jian HUANG Xian-hui ZENG Zhen-ling |
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| Institution: | LI Mei,LIU Wei-jian,HUANG Xian-hui,ZENG Zhen-ling(College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China) |
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| Abstract: | In routine breeding conditions,35 healthy adult pigs were randomly divided into seven groups,5 pigs each group.The long-acting doxycycline hydrochloride injection was administered intramuscularly at a dose of 10 mg/kg.Five pigs were sacrificed with exsanguinations at 12 h,2,5,9,14,19 and 25 d after last administration,and samples of rump muscle,injection site,liver,kidney and abdominal fat were collected.The doxycycline concentrations in muscle,injection site,liver,kidney and skint were determined by HPLC m... |
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| Keywords: | doxycycline swine tissue residue withdrawal period high-performance liquid chromatography |
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