| 端粒及其研究进展 |
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| 引用本文： | 常怀普,马志杰,钟金城.端粒及其研究进展[J].中国牛业科学,2006,32(5):43-47. |
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| 作者姓名： | 常怀普 马志杰 钟金城 |
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| 作者单位： | 1. 西南民族大学,生命科学与技术学院,四川,成都,610041
2. 青海省畜牧兽医科学院畜牧研究所,青海,西宁,810016 |
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| 摘 要： | 端粒是真核生物染色体末端的一种特殊结构,由端粒DNA和端粒相关蛋白组成,它能维持染色体的结构稳定和功能,保护其免受核酸酶降解,防止其末端融合或重排等。端粒长度的维持机制主要有ALT机制和TA机制。端粒长度的维持以及端粒酶的利用在衰老的控制中起重要作用。本文在系统论述端粒的结构、端粒的维持机制以及端粒与衰老的关系等研究进展的基础上,就当前该研究领域中存在的问题提出了个人的观点。
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| 关 键 词： | 端粒 端粒酶 衰老 |
| 文章编号： | 1001-9111（2006）05-0043-05 |
| 收稿时间： | 2006-04-11 |
| 修稿时间： | 2006年4月11日 |
Research Progress on Structure and Functions of Telomere |
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| CHANG Huai-pu,MA Zhi-jie,ZHONG Jin-cheng.Research Progress on Structure and Functions of Telomere[J].China Cattle Science,2006,32(5):43-47. |
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| Authors: | CHANG Huai-pu MA Zhi-jie ZHONG Jin-cheng |
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| Institution: | 1. College of Life Sciences and Technology of Southwest University for Nationalities, Chengdu , Sichuan 610041, China ; 2. Institute of Animal Husbandry of Qinghai Academy of Animal Husbandry and Veterinary, Xinin g , Qin ghai 810016, China |
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| Abstract: | Telomeres, as a special structures capping eukaryotic chromosome ends, composed of telomeric DNA and telomere-associated protein, being used to keep the structural stability and function of the chromosomes, and protect them from digestions, end - to - end fusions, rearrangements, and so on. ALT and TA mechanisms are dominant maintenance mechanisms of the telomere length. The maintenance of telomere length and the utilization of the telomerase played a key role in the control of the aging. Research developments on structure of the telomere, mechanism of telomere maintenance and relation between the telomere and aging are systematically discussed. Besides, some personal, views were proposed in the review according to the problems existing in the relative fields at present. |
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| Keywords: | Telomere Telomerase Aging |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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