Inheritance of diabetes mellitus in Keeshond dogs |
| |
Authors: | J W Kramer J K Klaassen D G Baskin D J Prieur N W Rantanen J D Robinette W R Graber L Rashti |
| |
Institution: | College of Veterinary Medicine, Washington State University, Pullman 99164. |
| |
Abstract: | The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive. |
| |
Keywords: | |
|
|