| 寄生线虫RNA干扰研究进展 |
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| 引用本文： | 贺现辉,朱兴全,徐民俊.寄生线虫RNA干扰研究进展[J].中国畜牧兽医,2011,38(3):65-68. |
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| 作者姓名： | 贺现辉 朱兴全 徐民俊 |
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| 作者单位： | （1.华南农业大学兽医学院，广东广州 510642；2.中国农业科学院兰州兽医研究所 家畜疫病病原生物学国家重点实验室，甘肃兰州 730046) |
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| 基金项目： | 家畜疫病病原生物学国家重点实验室开放基金，中国博士后基金 |
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| 摘 要： | 基因的RNA干扰（RNA interference,RNAi）技术是一个功能强大的基因组学研究工具。机体内存在特定的双链RNA（dsRNA）对基因的表达有干扰作用，可以引起基因沉默现象。通过外源dsRNA对寄生线虫进行RNA干扰研究，有助于了解不同发育期的特征现象和特定基因的生物学功能。此外，寄生线虫的RNA干扰研究对RNA干扰技术本身的发展也有较大促进作用。作者总结了近几年来RNA干扰技术在寄生线虫方面的最新研究进展，以期为相关研究工作提供参考。
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| 关 键 词： | 寄生虫 线虫 RNA干扰 双链RNA 基因沉默 |
Advances in RNA Interference Studies in Parasitic Nematodes |
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| HE Xian-hui,ZHU Xing-quan,XU Min-jun.Advances in RNA Interference Studies in Parasitic Nematodes[J].China Animal Husbandry & Veterinary Medicine,2011,38(3):65-68. |
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| Authors: | HE Xian-hui ZHU Xing-quan XU Min-jun |
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| Institution: | 〗(1.College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China；2.State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China) |
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| Abstract: | RNA interference(RNAi) is a powerful tool for genomics research. It was found that gene expression can be interfered by double-stranded RNA(dsRNA) which led to silence of the target gene. RNA interference in parasitic nematodes with exogenous dsRNA helps understand the characteristics of different developmental stages and the biological functions of aimed genes. On the other hand, the study of RNA interference in parasitic nematodes will promote the RNAi technology itself. The present article reviewed the research progresses in RNAi studies in parasitic nematodes in recent years, which would provide references for related research. |
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| Keywords: | parasite nematodes RNA interference(RNAi) double-stranded RNA(dsRNA) gene silence |
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