鹿茸再生及其分子调节机理研究进展

鹿茸是唯一可以周期性完全再生的哺乳动物器官,这种再生起源于骨膜干细胞。鹿茸再生伴随着皮肤、血管和神经的快速生成,而且多种多肽和生长因子参与其中,组成了一系列复杂而精密的信号调控通路。作者综述了鹿茸再生过程的组织学及分子信号通路研究现状,以信号转导通路为研究重点揭示鹿茸再生之谜,为更好地了解哺乳动物器官再生机制提供参考。

Research Progress on Antler Regeneration and its Molecular Regulate

Deer antlers, derivatives of periosteum cells, are the only mammalian appendages capable of full renewal in yearly cycle. Antler regeneration along with the rapid generation of skin, blood vessels and nerves, and a variety of peptides and growth factors are involved, all of that are regulated by a series of complex and sophisticated signal pathways. This paper summarizes the histological progress of antler regeneration and the present research status of signaling pathways thereof, with a focus on signal transduction pathways to reveal the mystery of antler regeneration, with the aim to gain a better understanding of the mechanism of mammalian organ regeneration.