细胞因子在抗鸡球虫感染中的作用及应用

鸡球虫病是由艾美耳球虫感染引起的一种严重危害养禽业的寄生虫病,被认为是对养禽业最具经济破坏力的疾病之一,每年可引起巨大的经济损失。目前鸡球虫病的防制主要依赖于药物,但由于抗药性、药物残留等问题,人们日益重视用免疫学方法来预防和控制鸡球虫病。细胞因子在免疫应答及抗感染过程中起重要作用,近30年来,随着对细胞因子种类及其功能的不断发现,它们在抗球虫方面的作用也引起研究者的重视。研究细胞因子的产生和作用有利于深入了解抗球虫感染的免疫调控和免疫效应机制,为免疫增强剂、免疫佐剂的使用和提高免疫效果提供依据。

Role and Application of Cytokines against Chicken Coccidiosis

Coccidiosis caused by protozoan parasites of the genus Eimeria has a severe economic impact on poultry production worldwide. The disease is considered as one of the most economically devastating infectious diseases and can cause huge economic losses each year. Currently, the control of coccidiosis is mainly relied on the use of chemoprophylaxis agents. However,the emergence of drug-resistant strains in the field, and increasing concerns raised over the drug residues inpoultry products, force people to explore alternative ways, such as immunological method, to control the Eimeria infection. Cytokines play an important role on immune response and anti-infection process. In recent three decades, with the development of studies on their types and functions, the roles of cytokines on anti-coccidia also attract the attention of more researchers. Studies on the production and the role of cytokines, should help to understand the immune regulation and immune response mechanisms, and provide foundation to strengthen immune effect with the use of immunopotentiator and immune adjuvant.