白细胞介素 2对犬细小病毒疫苗免疫效果的影响

为研究白细胞介素 2（IL-2）对犬细小病毒疫苗免疫效果的影响，选择40只幼犬，随机分成试验组和对照组，试验组按0.5 ml/头份加入犬用IL-2与犬细小病毒疫苗一起皮下注射，对照组单独使用犬细小病毒疫苗，注射后分别在接种前、接种后7 d和14 d使用金标试纸条检测其抗体效价，并进行组间抗体效价差异的t检验。试验结果表明，接种疫苗前试验组与对照组犬细小病毒平均抗体效价之间差异不显著；接种疫苗后7 d，试验组与对照组犬细小病毒平均抗体效价差异极显著(P<0.01)；接种疫苗后14 d，试验组与对照组犬细小病毒平均抗体效价差异极显著(P<0.01)。试验表明：IL 2可明显提高幼犬对犬细小病毒疫苗的抗体应答能力，是一种良好的犬细小病毒疫苗候选佐剂。

Effect of IL 〖STHZ〗2 on Immune Efficacy of Canine Parvovirus Vaccine

In order to study the effect of IL 2 on the canine parvovirus vaccine efficacy, 40 puppies were randomly divided into control group and the experimental group, canine parvovirus vaccine and the vaccine plus 0.5 ml/head IL-2 injection was inoculated respectively. Post 7 days and 14 days, the standard test paper was used to detect antibody titer of the two groups. Results: The antibody titer revealed no significant difference between the test and control group before inoculation; Seven days post vaccination, antibody titer of the test group were very significant difference (P<0.01); 14 days post vaccination, there were very significant difference (P<0.01) between the test and the control groups in antibody titers. Experiments showed that IL-2 can significantly improve the efficacy of canine parvovirus vaccine. IL-2 is a good candidate canine parvovirus vauine adjuvant.