| 制备双特异性单克隆抗体的方法 |
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| 引用本文： | 刘庆涛,谭长江,潘志忠,臧丽,张乃生.制备双特异性单克隆抗体的方法[J].中国畜牧兽医,2007,34(4):49-52. |
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| 作者姓名： | 刘庆涛 谭长江 潘志忠 臧丽 张乃生 |
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| 作者单位： | 1.吉林大学畜牧兽医学院，长春 130062；2.七级动物防疫监督站，即墨 266233 |
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| 摘 要： | 双特异性抗体由于其独特的结构－2个不同抗原，引起研究机构的广泛重视。研究者将治疗药物和针对疾病部位的特异目标分别放在双特异性单克隆抗体的2个臂上。治疗药物可以是药品、毒素、酶、DNA和放射性核素等。双特异性单克隆抗体能使免疫效应细胞的细胞毒性作用于致病细胞或者诱导产生全身免疫应答。作者重点介绍了制备双特异性单克隆抗体的3种方法，分别是化学方法、生物方法和基因工程，为制备临床需要的抗体奠定坚实的理论基础。
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| 关 键 词： | 双特异性单克隆抗体 制备 方法 |
| 文章编号： | 1671-7236（2007）04-0049-03 |
| 修稿时间： | 2006-10-09 |
Methods to Prepare Bispecific Monoclonal Antibodies |
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| LIU Qing-tao,TAN Chang-jiang,PAN Zhi-zhong,ZANG Li,ZHANG Nai-sheng.Methods to Prepare Bispecific Monoclonal Antibodies[J].China Animal Husbandry & Veterinary Medicine,2007,34(4):49-52. |
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| Authors: | LIU Qing-tao TAN Chang-jiang PAN Zhi-zhong ZANG Li ZHANG Nai-sheng |
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| Institution: | 1.College of Animal Science and Veterinary Medicine in Jinlin University,Changchun 130062，China； 2.Animal Supervision Station of Epidemic Prevention in Seventh Class,Jimo 266233，China |
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| Abstract: | Bispecific monoclonal antibodies have drawn considerable attention from the research community due to their unique structure against two different antigens.The two-arm structure of BsMAb allows researchers to place a therapeutic agent on one arm while allowing the other to specifically target the disease site.The the-rapeutic agent can be a drug,toxin,enzyme,DNA,radionuclide,etc.Furthermo-re,bsMAb may redirect the cytotoxicity of immune effector cells toward the diseased cell or induce a systemic immune response against the target.This review focuses on therapeutic applications and production of bsMAb while providing the up-to-date clinical trial information. |
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| Keywords: | bispecific monoclonal antibodies preparation methods |
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