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白细胞介素-2对犬细小病毒疫苗免疫效果的影响
引用本文:肖啸,杨继生,李松彪,杨林富.白细胞介素-2对犬细小病毒疫苗免疫效果的影响[J].中国畜牧兽医,2008,35(7).
作者姓名:肖啸  杨继生  李松彪  杨林富
作者单位:1. 云南农业大学动物科学学院,昆明,650201;云南农业大学动物医院,昆明,650201
2. 云南农业大学动物科学学院,昆明,650201
3. 河南科技大学,洛阳,471003
摘    要:为研究白细胞介素-2(IL-2)对犬细小病毒疫苗免疫效果的影响,选择40只幼犬,随机分成试验组和对照组,试验组按0.5 ml/头份加入犬用IL-2与犬细小病毒疫苗一起皮下注射,对照组单独使用犬细小病毒疫苗,注射后分别在接种前、接种后7 d和14 d使用金标试纸条检测其抗体效价,并进行组间抗体效价差异的t检验。试验结果表明,接种疫苗前试验组与对照组犬细小病毒平均抗体效价之间差异不显著;接种疫苗后7 d,试验组与对照组犬细小病毒平均抗体效价差异极显著(P<0.01);接种疫苗后14 d,试验组与对照组犬细小病毒平均抗体效价差异极显著(P<0.01)。试验表明:IL-2可明显提高幼犬对犬细小病毒疫苗的抗体应答能力,是一种良好的犬细小病毒疫苗候选佐剂。

关 键 词:白细胞介素-2  犬细小病毒  免疫效果

Effect of IL-2 on Immune Efficacy of Canine Parvovirus Vaccine
XIAO Xiao,YANG Ji-sheng,LI Song-biao,YANG Lin-fu.Effect of IL-2 on Immune Efficacy of Canine Parvovirus Vaccine[J].China Animal Husbandry & Veterinary Medicine,2008,35(7).
Authors:XIAO Xiao    YANG Ji-sheng  LI Song-biao  YANG Lin-fu
Institution:XIAO Xiao1,2,YANG Ji-sheng1,LI Song-biao3,YANG Lin-fu1
Abstract:In order to study the effect of IL-2 on the canine parvovirus vaccine efficacy,40 puppies were randomly divided into control group and the experimental group,canine parvovirus vaccine and the vaccine plus 0.5 ml/head IL-2 injection was inoculated respectively.Post 7 days and 14 days,the standard test paper was used to detect antibody titer of the two groups.Results: The antibody titer revealed no significant difference between the test and control group before inoculation;Seven days post vaccination,antibody titer of the test group were very significant difference(P<0.01);14 days post vaccination,there were very significant difference(P<0.01) between the test and the control groups in antibody titers.Experiments showed that IL-2 can significantly improve the efficacy of canine parvovirus vaccine.IL-2 is a good candidate canine parvovirus vauine adjuvant.
Keywords:IL-2  canine parvovirus  immune effect
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