| 哺乳动物性晚熟相关基因的研究进展 |
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| 引用本文： | 冯涛,狄冉,储明星,张英杰.哺乳动物性晚熟相关基因的研究进展[J].中国畜牧兽医,2009,36(2):86-89. |
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| 作者姓名： | 冯涛 狄冉 储明星 张英杰 |
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| 作者单位： | （1.甘肃农业大学动物科学技术学院，兰州 730070； 2.中国农业科学院北京畜牧兽医研究所，中国农业科学院家养动物遗传资源与种质创新重点开放实验室，北京 100193； 3.河北农业大学动物科技学院，保定 071000） |
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| 基金项目： | 国家重点基础研究发展规划(973计划)，国家高技术研究发展计划(863计划)，国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | 人和哺乳动物性的发育和成熟源于下丘脑性腺激素释放激素（gonadotropin releasing hormone，GnRH）脉冲式释放。GnRH释放受到抑制或破坏，就会导致性腺机能减退，人在发育前和发育期就会出现发育迟缓和性发育不良，表现为无精症或闭经；动物则表现为初情期延迟、生殖能力下降等表型。编码促性腺激素及其受体基因的突变可能引起哺乳动物性晚熟。笔者简要介绍了GPR54、GnRH/GnRHR、FSH/FSHR、LH/LHR基因与哺乳动物性晚熟的关系。
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| 关 键 词： | 性晚熟 基因 突变 |
Advances on Related Genes with Delayed Puberty in Mammals |
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| FENG Tao,DI Ran,CHU Ming-xing,ZHANG Ying-jie.Advances on Related Genes with Delayed Puberty in Mammals[J].China Animal Husbandry & Veterinary Medicine,2009,36(2):86-89. |
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| Authors: | FENG Tao DI Ran CHU Ming-xing ZHANG Ying-jie |
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| Institution: | （1.College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;2. The Key Laboratory of Domestic Animal Genetic Resources and Germplasm Innovation of CAAS, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China;3. College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China） |
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| Abstract: | Sexual maturation of humans and mammals was driven by an intermittent discharge of gonadotropin releasing hormone (GnRH) generated by a network of hypothalamic neurons known as the GnRH pulse generator. Reproductive disorder will present once GnRH release was suppressed or destroyed, which will result in hypothalamic hypogonadism. As for humans, this disorder presents azoospermatism and amenorrhea resulted from hypoevolutismus and sex hypoplasia. Animals affected by hypothalamic hypogonadism present puberty delay and reproductive capacity degression. Mutations of the genes encoding gonadotrophins and their receptors may cause delayed puberty. This review briefly introduced the relationships between GPR54, GnRH/GnRHR, FSH/FSHR, LH/LHR genes and delayed puberty in mammals. |
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| Keywords: | delayed puberty gene mutation |
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