新城疫复合物疫苗对1日龄雏鸡免疫效果的研究

用新城疫病毒La Sota株作为复合物疫苗抗原，与新城疫特异性中和抗体混匀配制成4种不同比例的复合物疫苗，用1日龄普通雏鸡进行免疫效果对比试验。试验1~4组分别为免疫复合物疫苗1~4，试验5组免疫常规新城疫活苗，试验6组为空白对照组。免疫后3周采血测定HI抗体效价，同时用新城疫强毒北京株F48E9攻击。试验结果显示，试验1~6组HI抗体效价分别为3.2log2、3.1log2、3.3log2、3.2log2、3.1log2、2.9log2；攻毒后，试验1~6组鸡的死亡率分别为15%、20%、0%、35%、30%、50%。因此，新城疫病毒La Sota株与新城疫特异性抗体制备成复合物疫苗，能保持疫苗中抗原的免疫原性，并可减轻疫苗的毒副作用，提高疫苗的安全性，其免疫效果比常规活苗好。

Studies on the Immunity Effect of Newcastle Disease Complex Vaccine in One-day Old Common Chick

Four kind of complex vaccines were composed of NDV La Sota strain and the specific antibody against NDV in different ratios,the immunity effect test of vaccines were carried out with one-day old common chicks.Chicks in group 1 to 4 were vaccinated with complex vaccines 1 to 4 respectively,chicks in group 5 were vaccinated with La Sota live vaccine,and chicks in group 6 were not vaccinated with any vaccine.Blood samples were taken post-immunization three weeks,and levels of anti-NDV antibody were tested by H...