| 减毒沙门氏菌作为口服活疫苗载体的研究进展 |
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| 引用本文： | 马全英,安芳兰,刘萍,祝秀梅,吕志慧,王凡,刘学荣,黄银君,牟克斌.减毒沙门氏菌作为口服活疫苗载体的研究进展[J].贵州畜牧兽医,2012,36(5):16-20. |
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| 作者姓名： | 马全英 安芳兰 刘萍 祝秀梅 吕志慧 王凡 刘学荣 黄银君 牟克斌 |
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| 作者单位： | 甘肃省兰州中农威特生物科技股份有限公司,甘肃兰州,730046 |
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| 摘 要： | 文章就沙门氏菌相关基因的特点、减毒沙门氏菌载体激发的免疫应答、进入机体免疫系统的机制、减毒沙门氏菌的应用、载体疫苗的优越性及潜在危险性几方面综述了减毒沙门氏菌作为口服疫苗载体的研究进展,为新型菌苗的研制提供一种新的思路。
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| 关 键 词： | 减毒沙门氏菌 活载体疫苗 基因减毒 免疫机制 |
The Research Progress of the Orally Attenuated Recombinant Salmonella Typhimurium Vector Vaccine |
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| Ma Quanying,An Fanglan,Liu Ping,Zhu Xiumei,Lu Zhihui,Wang Fan,Liu Xuerong,Huang Yinjun,Mu Kebin.The Research Progress of the Orally Attenuated Recombinant Salmonella Typhimurium Vector Vaccine[J].Guizhou Animal Science and Veterinary Medicine,2012,36(5):16-20. |
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| Authors: | Ma Quanying An Fanglan Liu Ping Zhu Xiumei Lu Zhihui Wang Fan Liu Xuerong Huang Yinjun Mu Kebin |
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| Institution: | (China Agricultural Veterinary Biological Science and Technology Company Limited ,Lanzhou Gansu 730046, China) |
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| Abstract: | This article related genes from Salmonella characteristics of the related gene, attenuation salmonella carrier stimulate the immune re- sponse, into the mechanism of the immune system, the application of attenuated salmonella typhimurium, the superiority of vaccine vectors potentially dangerous areas and review of the attenuated salmonella as oral progress in a new type vaccine vectors for the development of novel vaccine provides a new way of thinking. |
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| Keywords: | Attenuated Salmonella Live Vector Vaccine Attenuation by Mutated Gene Immunologic Mechanism |
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