对氯苯乙酮肟醚衍生物的合成及生物活性

为寻找高活性的新农药化合物,通过2-取代氨基-1-对氯苯乙酮-1-肟与卤代烃反应,设计并合成了35个对氯苯乙酮肟醚衍生物,其结构均经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,该类化合物具有一定的杀虫、抑菌及除草活性,其中 C9、C12 在500 mg/L时对蚜虫Aphis craccivaora的致死率达到100%; C10、C12、C15和C23 在1 000 mg/L时对朱砂叶螨Tetranychus cinabarinus的致死率达到100%; C29、C30和C31 在500 mg/L时对黄瓜白粉病菌Sphaerotheca fuligineas的抑制率达到95%以上; C29、C30、C33和C35 在100 mg/L时对马唐Digitaria sanguinalis的抑制率达到90%以上。

Synthesis and Bioactivity of 4-Chlorophenyl Methyl Ketone Oxime Ether Derivatives

In search of novel pesticide leading compound with high bioactivity,thirty-five 4-chloro-phenyl methyl ketone oxime ether derivatives were designed and synthesized by the reaction of 2-substituted amino 4-chlorophenyl methyl ketone oxime with halohydrocarbon.The structure of all novel compounds was confirmed by 1H NMR and elemental analysis.Preliminary bioassays showed that some compounds exhibited certain insecticidal and herbicidal activities.The mortality of C9,C12 to Aphis craccivaora reached 100% at the concentration of 500 mg/L.The mortality of C10,C12,C15 and C23 to Tetranychus cinabarinus reached 100% at 1 000 mg/L.The inhibition rate of C29,C30 and C31 to Sphaerotheca fuligineas was over 95% at the concentration of 500 mg/L.The inhibition rate of C29,C30,C33 and C35 to Digitaria sanguinalis was over 90% at the concentration of 100 mg/L.