| 流动相添加剂法与手性固定相法对己唑醇光学异构体的拆分 |
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| 引用本文： | 杨丽,江树人,廖勇,王鹏,田芹,周志强.流动相添加剂法与手性固定相法对己唑醇光学异构体的拆分[J].农药学学报,2004,6(2):90-92. |
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| 作者姓名： | 杨丽 江树人 廖勇 王鹏 田芹 周志强 |
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| 作者单位： | 1.中国农业大学 应用化学系,北京 100094 |
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| 摘 要： | 分别采用β-环糊精作为手性流动相添加剂的反相高效液相色谱法和涂敷型纤维素-三(3,5-二甲基苯基氨基甲酸酯)正相高效液相色谱手性固定相法拆分了农药己唑醇。结果表明,己唑醇对映异构体在以上两种方法下都完全达到基线分离。考察了影响容量因子、选择性系数和分离度的各种因素。
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| 关 键 词： | 高效液相色谱 手性固定相 手性流动相添加剂 己唑醇 对映体拆分 |
| 文章编号： | 1008-7303(2004)02-0090-03 |
| 收稿时间： | 2003/10/24 0:00:00 |
| 修稿时间： | 2003年10月24 |
Chiral Separation of Hexaconazole by Reversed Phase HPLC with β-Cyclodex trin as a Mobile Phase and Normal Phase HPLC with CDMPC as Chiral Stationary Phase |
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| YANG Li,JIANG Shu-ren,LIAO Yong,WANG Peng,TIAN Qin and ZHOU Zhi-qiang.Chiral Separation of Hexaconazole by Reversed Phase HPLC with β-Cyclodex trin as a Mobile Phase and Normal Phase HPLC with CDMPC as Chiral Stationary Phase[J].Chinese Journal of Pesticide Science,2004,6(2):90-92. |
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| Authors: | YANG Li JIANG Shu-ren LIAO Yong WANG Peng TIAN Qin and ZHOU Zhi-qiang |
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| Institution: | 1.Department of Applied Chemistry, China Agricultural University, Beijing 100094, China2.Institute of Genetics and Developmental Biology, Chinese Academy of Science, Beijing 100101, China |
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| Abstract: | Chiral separation of hexaconazole enantiomers was realized by reversed phase HPLC with β-cyclodextrin as a mobile phase and normal phase HPLC with CDMPC as chiral stationary phase. With reversed phase HPLC, the effect of the content of β-CD, pH of mobile phase and organic modifier on the chiral separation was studied. And the effect of 2-propanol concentration on the retention and resolution of CDMPC was investigated also. The results show that excellent enantioseparation can be achieved for hexaconazole by these two methods under the optimal conditions. |
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| Keywords: | HPLC chiral stationary phase chiral mobile phase additive hexaconazole (enantiomers) separation |
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