| 商陆中三萜皂苷类成分抗烟草花叶病毒活性研究 |
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| 引用本文： | 葛永辉,罗焕平,郑钰,陈兴江,耿召良.商陆中三萜皂苷类成分抗烟草花叶病毒活性研究[J].农药学学报,2015,17(3):300-306. |
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| 作者姓名： | 葛永辉 罗焕平 郑钰 陈兴江 耿召良 |
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| 作者单位： | 1.贵州省烟草科学研究院, 贵阳 550081 |
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| 摘 要： | 从垂序商陆中筛选具有抗烟草花叶病毒(Tobacco mosaic virus,TMV)活性的小分子化合物,为开发高效、低毒和环境友好的天然抗病毒剂提供依据。通过现代化分离、纯化技术,采用活性追踪的方法,对采自于贵州省的垂序商陆中的化学成分进行抗TMV活性逐级筛选,获得了两个抗TM V活性较强的三萜皂苷类化合物—商陆皂苷丁和商陆皂苷H,利用光谱解析手段确定了化合物的结构。生物活性测定结果表明:商陆皂苷丁和商陆皂苷H均具有一定的活体钝化与抑制病毒增殖作用,其中活体钝化及病毒增殖抑制作用均强于对照药物宁南霉素。该研究首次发现垂序商陆中的三萜皂苷类化合物具有抗TMV的活性,为下一步系统研究该种植物提供了科学依据。
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| 关 键 词： | 垂序商陆 三萜皂苷丁 三萜皂苷H 抗烟草花叶病毒活性 |
| 收稿时间： | 2014/7/30 0:00:00 |
| 修稿时间： | 2/1/2015 12:00:00 AM |
Anti tobacco mosaic virus activity of triterpenoidsaponin from Phytolacca americana L. |
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| Ge Yonghui,Luo Huanping,Zheng Jue,Chen Xingjiang and Geng Zhaoliang.Anti tobacco mosaic virus activity of triterpenoidsaponin from Phytolacca americana L.[J].Chinese Journal of Pesticide Science,2015,17(3):300-306. |
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| Authors: | Ge Yonghui Luo Huanping Zheng Jue Chen Xingjiang and Geng Zhaoliang |
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| Institution: | 1.Guizhou Academy of Tobacco Science, Guiyang 550081, China2.Bijie Branch of Guizhou Provincial Tobacco Corporation, Bijie 551700, Guizhou Province, China |
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| Abstract: | Small molecules isolated from Phytolacca americana L. grown in Guizhou province were evaluated for their anti tobacco mosaic virus (TMV) properties. Two triterpenoidsaponin compounds, eseulentoside D and esculentoside H showed higher activities than ningnanmycin AS. Their structures were determined by 1H NMR and IR analysis. Notably, it is the first time that triterpenoidsaponin compounds from P.americana was found with anti-TMV activity. This research provides useful information for the systemically study of P.americana. It is also high valuable for developing efficient, low toxicity, environmental friendly antiviral agents. |
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| Keywords: | Phytolacca Americana L eseulentoside D esculentoside H anti-TMV activity |
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