| 环磺酮原药中3个杂质结构的确定及其合成 |
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| 引用本文： | 黄朋勉,周智慧,吴鸿,周玲,丁慧,伍斌,赵东江,黄超群.环磺酮原药中3个杂质结构的确定及其合成[J].农药学学报,2019,21(2):233-237. |
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| 作者姓名： | 黄朋勉 周智慧 吴鸿 周玲 丁慧 伍斌 赵东江 黄超群 |
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| 作者单位： | 1.长沙理工大学 化学与食品工程学院，长沙 410114 |
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| 基金项目： | 长沙市科技计划项目经费资助（kq1801163，kq1801052）；湖南省水生资源食品加工工程技术研究中心开放基金资助项目（2018KJY08） |
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| 摘 要： | 采用文献中报道的环磺酮的合成工艺合成了环磺酮原药，通过高效液相色谱分析，发现其原药中含有3个质量分数分别大于0.1%的杂质；通过核磁共振氢谱 (1H NMR) 及高分辨质谱 (HRMS) 对3个杂质的结构进行了确证，同时进行了合成。根据合成工艺路线，对该杂质产生的途径进行了分析。
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| 关 键 词： | 环磺酮 杂质 合成 机理研究 |
| 收稿时间： | 2018/9/6 0:00:00 |
Characterization and synthesis of three impurities in tembotrione |
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| HUANG Pengmian,ZHOU Zhihui,WU Hong,ZHOU Ling,DING Hui,WU Bin,ZHAO Dongjiang and HUANG Chaoqun.Characterization and synthesis of three impurities in tembotrione[J].Chinese Journal of Pesticide Science,2019,21(2):233-237. |
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| Authors: | HUANG Pengmian ZHOU Zhihui WU Hong ZHOU Ling DING Hui WU Bin ZHAO Dongjiang and HUANG Chaoqun |
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| Institution: | 1.School of Chemistry and Food Engineering, Changsha University of Science & Technology, Changsha 410114, China2.Changsha Jiaqiao Biotech Co., Ltd., Changsha 410000, China |
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| Abstract: | Tembotrione was prepared according to the reported method. Three main impurities over 0.1% were detected by high-performance liquid chromatography (HPLC). The structures of those impurities were characterized by 1H NMR and high resolution mass spectrometer (HRMS). Then the impurities were synthesized. The produced pathways of impurities were also analyzed according to the synthetic route. |
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| Keywords: | tembotrione impurities synthesis mechanism study |
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