| 呋喃磺草酮原药中主要杂质的结构鉴定及其合成 |
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| 引用本文： | 黄朋勉,王梓鉴,赵东江,黄超群,周智慧.呋喃磺草酮原药中主要杂质的结构鉴定及其合成[J].农药学学报,2020,22(1):171-175. |
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| 作者姓名： | 黄朋勉 王梓鉴 赵东江 黄超群 周智慧 |
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| 作者单位： | 长沙理工大学化学与食品工程学院,长沙 410114;长沙理工大学公路工程教育部重点实验室,长沙 410114;长沙理工大学化学与食品工程学院,长沙 410114;长沙嘉桥生物科技有限公司,长沙 410000 |
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| 基金项目： | 长沙市科技计划项目经费资助 (kq1801163，kq1801052)；湖南省水生资源食品加工工程技术研究中心开放基金资助项目 (2018KJY08)；长沙理工大学公路工程教育部重点实验室开放基金资助项目 (kfj090107) |
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| 摘 要： | 针对HPPD除草剂呋喃磺草酮原药生产中产生的3个质量分数均大于0.1%的主要杂质,通过高效液相色谱、核磁共振氢谱和高分辨质谱对3个杂质的结构进行了结构鉴定,发现其中2个为未见文献报道的化合物。结合生产工艺对杂质产生的路径进行了分析,并成功进行了合成。该研究对呋喃草酮原药质量控制和安全产生具有重要意义。
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| 关 键 词： | 呋喃磺草酮 杂质 结构鉴定 合成 |
| 收稿时间： | 2019-07-23 |
Structural identification and synthesis of main impurities in tefuryltrione |
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| HUANG Pengmian,WANG Zijian,ZHAO Dongjiang,HUANG Chaoqun,ZHOU Zhihui.Structural identification and synthesis of main impurities in tefuryltrione[J].Chinese Journal of Pesticide Science,2020,22(1):171-175. |
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| Authors: | HUANG Pengmian WANG Zijian ZHAO Dongjiang HUANG Chaoqun ZHOU Zhihui |
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| Institution: | 1.Academic Institution of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China2.Key Laboratory of Highway Engineering of Ministry of Education, Changsha University of Science & Technology, Changsha 410114, China3.Changsha Jiaqiao Biological Technology Co. Ltd., Changsha 410000, China |
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| Abstract: | In the preparation of tefuryltrione, three main impurities over 0.1%(wt) were detected by high-performance liquid chromatography. The structures of impurities were characterized by 1H NMR and HRMS. Two of those compounds were novel compounds. Then the impurities were synthesisezed by the modified synthetic route of tefuryltrione. The work will contribute to the quality control and safety production of tefuryltrione. |
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| Keywords: | tefuryltrione impurities structure identification synthesis |
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