| 手性农药毒性机制的对映体选择性 |
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| 引用本文： | 唐梦龄,王丹,傅柳松,刘维屏.手性农药毒性机制的对映体选择性[J].农药学学报,2011,13(4):335-340. |
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| 作者姓名： | 唐梦龄 王丹 傅柳松 刘维屏 |
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| 作者单位： | 1.浙江大学 环境与资源学院,杭州 310058 |
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| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目）;国家重点基础研究发展计划（973计划） |
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| 摘 要： | 综述了手性农药在急性毒性、慢性毒性、细胞毒性、藻类与植物毒性及生物体富集方面的对映体选择性差异。大量研究显示,手性农药的不同对映异构体对于非靶标作用体的毒性存在显著差异,这种选择性差异既取决于手性农药的对映异构体,同时又与作用的受体相关。探讨了手性农药毒理学研究的重点和发展方向——在对映体水平上对手性农药的毒理机制进行全面深入的研究,对于评价农药对健康的风险及生产绿色高效的单一或复合的对映体农药具有指导意义。
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| 关 键 词： | 手性农药 毒理 对映体选择性 综述 |
| 收稿时间： | 1/4/2011 12:00:00 AM |
| 修稿时间： | 6/9/2011 12:00:00 AM |
Enantioselectivity on toxic mechanisms of chiral pesticides |
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| TANG Meng-ling,WANG Dan,FU Liu-song and LIU Wei-ping.Enantioselectivity on toxic mechanisms of chiral pesticides[J].Chinese Journal of Pesticide Science,2011,13(4):335-340. |
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| Authors: | TANG Meng-ling WANG Dan FU Liu-song and LIU Wei-ping |
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| Institution: | 1.College of Environmental and Resource Science, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | This article illustrated the progress of chiral pesticide toxicology on the enantioselective level from the perspectives of chronic toxicity, acute toxicity, cytotoxicity, algae and plants, and the differences of bioaccumulation. Many researches showed that the toxicity of the enantiomers of chiral pesticides were significantly different to non-target receptor. The differences depend on the structure of the enantiomers and also the receptor. Discussing about the biological effects and toxicological mechanisms of chiral pesticides are meaningful to assess the health risk and to produce pure and enriched enantiomer of pesticides. |
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| Keywords: | chiral pesticide toxicity enantioselectivity review |
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