| 毒死蜱-聚乳酸微球的制备及其性能评价 |
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| 引用本文： | 郭瑞峰,黄彬彬,杨晓伟,吴祖建,吴刚.毒死蜱-聚乳酸微球的制备及其性能评价[J].农药学学报,2011,13(4):409-414. |
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| 作者姓名： | 郭瑞峰 黄彬彬 杨晓伟 吴祖建 吴刚 |
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| 作者单位： | 1.福建农林大学 生物农药与化学生物学教育部重点实验室,福州 350002 |
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| 基金项目： | 福建省科技厅项目(2009N0018;2009J01071). |
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| 摘 要： | 以毒死蜱为芯材,以生物可降解材料聚乳酸(PLA)为载体(壁材),采用溶剂挥发法制备了毒死蜱缓释微球,考察了芯壁材质量比及聚乳酸浓度对微球质量的影响。结果表明:当聚乳酸浓度增加时,载药量和包封率、粒径均随之增加;当芯壁材质量比减小(由1∶2减小至1∶5)时,微球粒 径、载药量也逐渐减小;包封率在芯壁材质量比为1∶3和1∶4时分别为89.88%±1.67%和90.55%±1.86%;当芯壁材质量比小于1∶2时,微球呈光滑完整的球形。差示扫描量热检测分析证明,毒死蜱和聚乳酸能够有机地结合为一体。表明合适的芯壁材比例和聚乳酸浓度有利于提高制备微球的质量。
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| 关 键 词： | 毒死蜱 聚乳酸 微球 缓释 |
| 收稿时间： | 2010/11/2 0:00:00 |
| 修稿时间： | 4/8/2011 12:00:00 AM |
Preparation and characteristics analysis of microspheres of chlorpyrifos and polylactic acid |
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| GUO Rui-feng,HUANG Bin-bin,YANG Xiao-wei,WU Zu-jian and WU Gang.Preparation and characteristics analysis of microspheres of chlorpyrifos and polylactic acid[J].Chinese Journal of Pesticide Science,2011,13(4):409-414. |
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| Authors: | GUO Rui-feng HUANG Bin-bin YANG Xiao-wei WU Zu-jian and WU Gang |
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| Institution: | 1.Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China |
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| Abstract: | The sustained-release microspheres of chlorpyrifos was prepared by solvent evaporation method using biodegradable polylactic acid(PLA) as wall materials and chlorpyrifos as core materials.The effects of ratio between core materials to wall materials(chlorpyrifos weight/ PLA weight,CP value) and the concentration of PLA on the characteristics of microsphere were investigated.The results indicated that particle diameter,drug-loading rate and entrapment efficiency of microsphere increased with the increase of ... |
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| Keywords: | chlorpyrifos microspheres polylactic acid (PLA) sustained-release |
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