Molecular analysis of resistance in a deltamethrin-resistant strain of Musca domestica from China |
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| Authors: | Xinghui Qiu Mei Li Tongsheng Fu |
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| Institution: | a State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
b Animal Medical College of Hunan Agricultural University, Changsha, Hunan 410128, China |
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| Abstract: | We investigated the molecular basis of resistance in a strain of house fly (BJD) from Beijing, China. This strain showed 567-fold resistance to commonly used deltamethrin. Flies were 64-fold resistant to deltamethrin synergized by piperonyl butoxide (PBO). The 5′-flanking sequence of the cytochrome P450 gene CYP6D1 in BJD strain had a 15-bp insert as in the LPR strain. Two mutations (kdr, super-kdr) in the voltage sensitive sodium channel (VSSC) were also detected in the BJD strain. Our results showed that a combination of resistance alleles for CYP6D1 and VSSC existed in deltamethrin resistant house flies in China. |
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| Keywords: | Cytochrome P450 monooxygenase CYP6D1 kdr super-kdr Musca domestica Resistance Pyrethroid |
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