Oxidative activation of O,S-dimethyl phosphoramidothiolate |
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Authors: | Morifusa Eto Sachiko Okabe Yoshihisa Ozoe Kazuyuki Maekawa |
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Institution: | Department of Agricultural Chemistry, Kyushu University, Fukuoka 812, Japan |
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Abstract: | O,S-Dimethyl phosphoramidothiolate, the insecticide methamidophos, is converted oxidatively into a potent anti-cholinesterase agent by the action of m-chloroperbenzoic acid. The active intermediate is not stable enough to be isolated. From some chemical evidence, the sulfoxide, i.e., dimethyl phosphoramidothiolate S-oxide, is most probably the active intermediate. A similar activation may occur by biological oxidation. |
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