Gut hormones in cyclostomes

The current state of knowledge about regulatory peptides in endocrine cells and nerves of the alimentary canal of lampreys and hagfishes is reviewed. Cyclostomes have a wide range of peptides similar immunochemically to those of higher vertebrates. They include, in the endocrine cells of the intestine, peptides resembling glucagon, gastrin/cholecystokinin, peptide YY (pancreatic polypeptide/neuropeptide Y), substance P, vasoactive intestinal peptide, somatostatin and, in the larval stages at least, insulin. The enteric nerves of some lamprey species contain peptides resembling bombesin (gastrin-releasing peptide) and calcitonin gene-related peptide, as well as serotonin. The occurrence of other peptides is less well documented. Little is known of the molecular structure or the biological roles of the enteric peptides in cyclostomes. Extraction, purification, sequencing and physiological experiments are greatly needed.