11-ketotestosterone potentiates estrogen-induced vitellogenin production in liver of Japanese eel (Anguilla japonica) |
| |
| Authors: | H Asanuma H Ohashi H Matsubara S Ijiri T Matsubara T Todo S Adachi K Yamauchi |
| |
| Institution: | 1. Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, 041-8611, Japan
2. Hokkaido National Fisheries Research Institute, Kushiro, 085-0802, Japan
|
| |
| Abstract: | Isolated hepatocytes from male Japanese eel at various stages of human chorionic gonadotropin (HCG)-induced spermatogenesis were cultured in the presence of estradiol-17β (E2). Hepatic vitellogenin (VTG) production in response to E2 increased during testicular development. This indicates that VTG production is influenced by gonadal maturity not only in females but also in males, where serum levels of 11-ketotestosterone (11KT) increase during testicular development. Recently, it has been confirmed that significant levels of 11KT are detected in maturing female eel. Therefore, in a next experiment, effect of 11KT on E2-induced VTG production was examined in vitro. As a result, in both male and female hepatocytes, 11KT enhanced E2-induced VTG production, although 11KT alone failed to induce VTG production. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
