Molecular mechanisms of sex determination and gonadal sex differentiation in fish |
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Authors: | Y Nagahama |
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Institution: | (1) Laboratory of Reproductive Biology, Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan;(2) CREST, Kawaguchi 332-0012, Japan |
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Abstract: | We have used various genetic and molecular approaches to investigate the mechanisms of sex determination and gonadal sex differentiation
in fish. DMY was identified as the sex-determining gene of medaka. In tilapia, endogenous estrogens act as natural inducers of ovarian
differentiation, while DMRT1 may be important for testicular differentiation. The roles of these regulators in sex determination and gonadal sex differentiation
were ascertained using a gene or hormonal blockade strategy. |
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Keywords: | Fish Sex-determining gene Estrogen DMRT1 Gonadal sex differentiation |
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