| 南极冰藻Chlamydomonas sp. ICE-L S-腺苷同型半胱氨酸水解酶基因的克隆及其生物信息学分析 |
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| 引用本文： | 王金慧,丁燏,简纪常,吴灶和.南极冰藻Chlamydomonas sp. ICE-L S-腺苷同型半胱氨酸水解酶基因的克隆及其生物信息学分析[J].中国水产科学,2011,18(6):1234-1242. |
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| 作者姓名： | 王金慧 丁燏 简纪常 吴灶和 |
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| 作者单位： | 广东海洋大学水产学院;广东省水产经济动物病原生物学及流行病学重点实验室,广东湛江,524025 |
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| 基金项目： | 国家自然科学基金资助项目，广东省自然科学基金资助项目 |
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| 摘 要： | S-腺苷同型半胱氨酸水解酶(S-adenosyl-L-homocysteine hydrolase,SAHH)是一种细胞内广泛存在的酶,在调节生物体转甲基化反应中占据重要地位.本研究通过RT-PCR及RACE-PCR技术克隆了南极冰藻(Ch lamydomonassp.ICE-L)S-腺苷同型半胱氨酸水解酶全序列,命名...
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| 关 键 词： | Chlamydomonas sp. ICE-L S-腺苷同型半胱氨酸水解酶 克隆 三维结构 生物信息学 |
| 修稿时间： | 2011/11/12 0:00:00 |
Molecular cloning and bioinformatics analysis of the S-adenosyl homocysteine hydrolase(SAHH)gene in the Antarctic ice alga Chlamydomonas sp. ICE-L (Chlamydomonadales, Chlamydomonas) |
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| WANG Jinhui,DING Yu,JIAN Jichang,WU Zaohe.Molecular cloning and bioinformatics analysis of the S-adenosyl homocysteine hydrolase(SAHH)gene in the Antarctic ice alga Chlamydomonas sp. ICE-L (Chlamydomonadales, Chlamydomonas)[J].Journal of Fishery Sciences of China,2011,18(6):1234-1242. |
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| Authors: | WANG Jinhui DING Yu JIAN Jichang WU Zaohe |
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| Institution: | WANG Jinhui,DING Yu,JIAN Jichang,WU Zaohe Fisheries College,Guangdong Ocean University,Guangdong Provincial Key Laboratory of Pathogenic Biology and Epidemi-ology for Aquatic Economic Animals,Zhanjiang,Guangdong 524025,China |
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| Abstract: | S-Adenosyl-L-methionine(SAM)is the most common methyl donor in a multitude of cellular methyla-tion reactions.Numerous methyltransferases transfer the methyl group from SAM to their respective biological acceptors,forming S-adenosyl-L-homocysteine(SAH).SAH is hydrolyzed to adenosine and L-homocysteine by S-adenosyl-L-homocysteine hydrolase(SAHH,EC 3.3.1.1).SAHH is an essential enzyme in all living cells,and has been explored as a potential drug target for many bacteria and parasites.The inhibition of SAHH a... |
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| Keywords: | Chlamydomonas sp ICE-L S-Adenosyl homocysteine hydrolase cloning 3D molecular modeling bioinformatics |
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