| 月桂酸单甘油酯对花鲈脂质代谢的影响 |
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| 引用本文： | 孙彩云,董宏标,王文豪,李勇,古群红,段亚飞,张家松,许晓东.月桂酸单甘油酯对花鲈脂质代谢的影响[J].南方水产科学,2021(1). |
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| 作者姓名： | 孙彩云 董宏标 王文豪 李勇 古群红 段亚飞 张家松 许晓东 |
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| 作者单位： | 水产科学国家级实验教学示范中心（上海海洋大学）;中国水产科学研究院南海水产研究所/农业农村部南海渔业资源开发利用重点实验室/广东省渔业生态环境重点实验室;中国水产科学研究院南海水产研究所深圳试验基地;珠海市现代农业发展中心;珠海德洋水产养殖有限公司 |
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| 基金项目： | 中国水产科学研究院南海水产研究所中央级公益性科研院所基本业务费专项资金资助(2017YB15);中国水产科学研究院基本科研业务费专项(2019XT0403);农业农村部南海渔业资源开发利用重点实验室开放基金(FREU2018-02);广州市科技计划项目(201904010169);中国-东盟海上合作基金项目“中国-东盟现代海洋渔业技术合作及产业化开发示范”;广东省现代农业产业技术体系创新团队建设项目(2019KJ150);国家重点研发计划项目(2019YFD0900500)。 |
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| 摘 要： | 为评价月桂酸单甘油酯(Glycerol monolaurate,GML)对花鲈(Lateolabrax maculatus)脂质代谢的影响,文章通过基础饲料拌喂0 mg·kg-1(对照组)、1000 mg·kg-1(低剂量组)、2000 mg·kg-1(中剂量组)和4000 mg·kg-1(高剂量组)的GML,养殖均质量为(230±20)g的花鲈8周。结果显示:1)添加GML组的腹脂率均显著降低,肝体比第4周明显降低(P<0.05);2)低剂量和中剂量组的血清甘油三酯、总胆固醇、低密度脂蛋白胆固醇浓度和天冬氨酸转氨酶活性均低于高剂量组(P<0.05);3)中剂量组的高密度脂蛋白胆固醇浓度均高于其他组(P<0.05);4)添加GML组肝脏中超氧化物歧化酶、谷胱甘肽过氧化物酶活性和还原型谷胱甘肽浓度均有升高,而丙二醛浓度显著降低(P<0.05);5)添加GML组的肝脏中脂肪酸合成酶和乙酰辅酶A羧化酶活性降低,且脂质沉积明显减少(P<0.05);脂蛋白脂酶活性均显著下降,中剂量组显著高于其他组(P<0.05)。综上,饲料中添加GML能够显著改善花鲈脂质代谢,该实验条件下,GML最适拌料量为2000 mg·kg-1。
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| 关 键 词： | 花鲈 月桂酸单甘油酯 脂质代谢 脂肪肝 |
Effects of glycerol monolaurate on lipid metabolism of Lateolabrax maculatus |
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| SUN Caiyun,DONG Hongbiao,WANG Wenhao,LI Yong,GU Qunhong,DUAN Yafei,ZHANG Jiasong,XU Xiaodong.Effects of glycerol monolaurate on lipid metabolism of Lateolabrax maculatus[J].South China Fisheries Science,2021(1). |
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| Authors: | SUN Caiyun DONG Hongbiao WANG Wenhao LI Yong GU Qunhong DUAN Yafei ZHANG Jiasong XU Xiaodong |
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| Institution: | (National Demonstration Center For Experimental Fisheries Science Education(Shanghai Ocean University),Shanghai 201306,China;South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences/Key Laboratory of South China Sea Fishery Resources Exploitation&Utilization,Ministry of Agriculture and Rural Affairs/Guangdong Provincial Key Laboratory of Fishery Ecology and Environment,Guangzhou 510300,China;Shenzhen Base of South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shenzhen 518121,China;Modern Agriculture Development Center of Zhuhai City,Zhuhai 519070,China;Zhuhai Deyang Aquaculture Co.,Ltd.,Zhuhai 519000,China) |
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| Abstract: | In this study,we evaluated the effect of glycerol monolaurate(GML)on lipid metabolism by feeding four diets containing 0 mg·kg-1(control group),1000 mg·kg-1(low-dose group),2000 mg·kg-1(medium-dose group)and 4000 mg·kg-1(high-dose group)on Lateolabrax maculatus with initial body mass of(230±20)g for eight weeks.The results show that:1)The intraperitoneal fat ratio(IPF)of the GML supplementation groups decreased significantly,and compared with the 4 th week,the hepatosomatic index(HIS)decreased significantly(P<0.05).2)The triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)contents and aspartate aminotransferase(AST)activities in low-and medium-dose groups were lower than those of high-dose group(P<0.05).3)The high-density lipoprotein cholesterol(HDL-C)contents in medium-dose group were higher than those of the other groups(P<0.05).4)The activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and the contents of glutathione(GSH)increased in the liver of the GML supplementation groups,while the malondialdehyde(MDA)contents decreased significantly(P<0.05).5)The activities of fatty acid synthase(FAS),acetyl-CoA carboxylase(ACC)and lipid deposition decreased in the liver of GML supplementation groups significantly(P<0.05);the lipoprotein lipase(LPL)activities in medium-dose group were significantly higher than those of the other groups(P<0.05).In summary,the dietary supplementation with GML can improve the lipid metabolism of L.maculatus significantly,and the suitable does is 2000 mg·kg-1. |
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| Keywords: | Lateolabrax maculatus Glycerol monolaurate Lipid metabolism Fatty liver |
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