双酚A和酞酸酯对鱼类的内分泌干扰效应和繁殖毒性的研究进展

环境雌激素作为一类内分泌干扰物进入人和动物体内后能干扰机体内分泌系统的正常功能，通过多种机制表现出拟天然雌激素或者抗天然雄激素的作用。双酚A（bisphenol A, BPA）和酞酸酯（也称作邻苯二甲酸酯，Phthalic Acid Esters, PAEs）是具有雌激素类活性的环境内分泌干扰物，广泛存在于水环境中，并对水生动物，特别是鱼类的安全造成潜在威胁。本文总结了目前BPA和PAEs对鱼类毒性效应的研究成果，特别是内分泌干扰作用和生殖毒性，为评估这两类环境污染物对鱼类的影响提供参考。

Research Progress of Endocrine-disrupting Effects and Reproductive Toxicity of Bisphenol A and Phthalic Acid Esters on Fish

Environmental estrogens, a group of endocrine disruptors, could enter human bodies and animals, and show estrogenic or anti-androgenic activities by diverse mechanisms, consequently disrupting their normal functions of the endocrine systems. Bisphenol A (BPA) and phthalate acid esters (PAEs) are endocrine-disrupting chemicals with estrogenic activities and widely present in aquatic environment. They have the potential threat on the aquatic animals especially on fish. In the present study, we summarized recent research progress regarding toxic effect of BPA and PAE to fish, particularly relating to endocrine-disrupting and reproductive toxicity. BPA and PAE pollution could disrupt endocrine of fish, destroy reproductive capacity and early stage of gondola development, affect the sexual differentiation and lead to the structural differentiation of gonadal tissue. This paper would provide a reference to the risk assessment of the two environmental contaminants on fish.