甲氧苄氨嘧啶在牙鲆体内的药代动力学研究

健康牙鲆口服剂量为100 mg/kg的甲氧苄氨嘧啶后,利用高效液相色谱测定药物在牙鲆肌肉、血液、肾脏、肝脏质量浓度变化,并通过3P87药动学软件分析数据。试验结果表明,甲氧苄氨嘧啶在肌肉、血液、肾脏、肝脏4种组织中均符合一级吸收二室开放模型,其在上述4种组织中的达峰时间(tmax)分别为18.72、12.942、3.13 h和19.49 h;达峰质量浓度分别为13.80、18.23、32.79、27.40μg/ml;消除半衰期分别为23.64、21.471、6.72 h和15.99 h。口服甲氧苄氨嘧啶,在牙鲆体内吸收与消除较慢,血药浓度高,维持时间长。

Pharmacokinetics of Trimethoprim in Japanese Flounder(Paralichthys olivaceus)

The trimethoprim(TMP)levels were analyzed in the muscle,blood,kidney and liver of Japanese flounder Paralichthys olivaceus orally administrated by reversed-phase high performance liquid chromatography and 3P87 softward to study the pharmacokinetics of TMP in the fish.The results showed a two-compartment open model best fitted the data in the four tissues.The major pharmacokinetic parameters in muscle,blood,kidney and liver were as follows,respectively:Time when maxium concentration(tmax)was obtained were 18...