The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in cattle

Efficacy of the paramunity inducer Baypamun (PIND-ORF) was evaluated by an IBR challenge trial in cattle, as one model for infectious diseases in bovine. Prophylactic treatment with Baypamun protected cattle against manifestation of clinical symptoms after experimental IBR infection. The degree of protection depended on the time between paramunization and challenge infection. Even in metaphylactically paramunized cattle Baypamun reduced the IBR symptoms. In correlation to the reduction of clinical symptoms paramunization also reduced virus excretion by more than 99% in treated cattle compared to non paramunized animals. The induction of interferon following IBR infection was investigated in paramunized cattle. Application of Baypamun enabled treated animals to react faster with interferon synthesis following IBR infection than control animals did. The demonstration of the status of paramunity following Baypamun application in cattle provides a concept in the prevention of infectious disease in the practice.