| 鲤鱼基因组同源框Hoxa3a序列同源性分析与分子进化研究 |
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| 引用本文： | 耿波,关云涛,孙效文,匡友谊.鲤鱼基因组同源框Hoxa3a序列同源性分析与分子进化研究[J].水产学杂志,2011,24(4):50-53. |
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| 作者姓名： | 耿波 关云涛 孙效文 匡友谊 |
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| 作者单位： | 1. 中国水产科学研究院黑龙江水产研究所,黑龙江哈尔滨,150070
2. 中国农业科学院哈尔滨兽医研究所兽医农业生物技术国家重点实验室,黑龙江哈尔滨,150001 |
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| 基金项目： | 国家计划(973)项目 |
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| 摘 要： | 本文利用生物信息学软件分析了鲤（Cyprinus carpio）基因组中同源框基因Hoxa3a与多种鱼类及其它生物的同源性,构建了分子进化树。结果表明：鲤与斑马鱼（Danio rerio）的序列同源性最高为95%,与大西洋鲑（Salmo salar）等四种鱼类的同源性次之为84%,与米氏叶吻银鲛（Callorhinch...
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| 关 键 词： | 鲤 同源框基因 序列同源性 分子进化 SNP |
Analysis of sequences homology and molecular evolution of Hoxa3a gene of common carp genome |
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| GENG Bo,GUAN Yun-tao,SUN Xiao-wen,KUANG You-yi.Analysis of sequences homology and molecular evolution of Hoxa3a gene of common carp genome[J].Chinese Journal of Fisheries,2011,24(4):50-53. |
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| Authors: | GENG Bo GUAN Yun-tao SUN Xiao-wen KUANG You-yi |
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| Institution: | 1(1.Heilongjiang Fisheries Research Institute,Chinese Academic of Fishery Sciences,Harbin 150070,China; 2.National Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150001,China) |
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| Abstract: | The sequence homology and molecular evolution of Hoxa3a gene were analyzed in common carp and other fishes and organisms by some bioinformatics softs.The results showed that the maximal sequence homology（up to 95%） was observed in common carp（Cyprinus carpio） and zebrafish（Danio rerio）,followed by Atlantic salmon（Salmo salar）,Japanese pufferfish（Takifugu rubripes）,Japanese medaka（Oryzias latipes） and Cichlid fish（Astatotilapia burtoni）（about 84%）,and the minimal（74.5%） in other fishes such as lttle skate（Leucoraja erinacea） and Australian ghost shark（Callorhinchus milii）.The sequence homology of common carp with three non-fish organisms was found to be 75%.This result also showed that Hox gene sequences were highly conserved evolutionarily.In the sequence comparison at the same time,two common carp SNP sites 101 site（T/C） and 213 site（C/T） were found.The result has great significance for the conservation of biological diversity（particularly genetic diversity） study and reveals the progress and mechanism of biological evolution. |
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| Keywords: | common carp homeobox gene（Hox gene） sequence homology molecular evolution SNP |
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