磺胺甲基异噁唑在大菱鲆体内的代谢动力学研究

采用高效液相色谱法测定血浆、肌肉和肝脏中的磺胺甲基异噁唑含量，通过3P97药动学软件对磺胺甲基异噁唑在大菱鲆体内的药代动力学规律进行了分析研究。研究结果表明，在（11±1）℃水温条件下，单次口灌100mg／kg磺胺甲基异噁唑（SMZ）,SMZ在大菱鲆肌肉、肝脏和血浆中的代谢过程均符合一级吸收一室模型。大菱鲆肌肉、肝脏和血浆中药物浓度分别在给药后11．89、10．53和4.87h达到最大值，Cmax分别为21．52、5．35和44．07mg／kg，给药后5、6d和72h含量低于最大残留限量（0．1mg／kg），18、24和10d后SMZ未检出（〈0．01mg／kg）。

Pharmacokinetics of sulfamethoxazole in turbot after oral administration

The pharmacokinetics, tissue metabolism and elimination of sulfamethoxazole (SMZ) was investigated in turbot Scophthalmus maximus following a single oral dose of 100mg/kg at (11±1)℃. Plasma and tissue concentration of SMZ was determined by HPLC. The concentration-time curves of SMZ in the muscle, liver and plasma fitted well to a one-compartment open model with first-order absorption. After the oral administration, the time to reach maximum SMZ concentration in the muscle, liver and plasma was 11.89 h, 10.53 h and 4.87 h, and the maximum concentration of SMZ was 21.52 mg/kg, 5.35 mg/kg and 44.07 mg/kg, respectively. 5 d, 6 d and 72 h after the administration, the SMZ content in the muscle, liver and plasma were less than the MRL (0.1 mg/kg); and it was undetectable at 18d, 24d and 10d in these tissues, respectively.