| 白斑综合征病毒囊膜蛋白VP19及VP28的研究进展 |
| |
| 引用本文： | 贾睿,朱婵,庄旻敏,廖圣瑜,施定基,何培民.白斑综合征病毒囊膜蛋白VP19及VP28的研究进展[J].水产学报,2020,44(5):870-880. |
| |
| 作者姓名： | 贾睿 朱婵 庄旻敏 廖圣瑜 施定基 何培民 |
| |
| 作者单位： | 上海海洋大学海洋生态与环境学院,上海 201306;上海海洋大学海洋生态与环境学院,上海 201306;中国科学院植物研究所,北京 100093 |
| |
| 基金项目： | 上海市农委科技兴农项目[沪农科推字(2017)第1-13号]；上海市科委创新项目(16391903500，17391902200)；国家“八六三”高技术研究发展计划(2014AA093506) |
| |
| 摘 要： | 自二十世纪90年代,白斑综合征病毒(WSSV)就因其暴发范围广、致死率高得到了广泛的关注。研究主要集中在确定该病毒蛋白的结构及功能,以及利用其囊膜蛋白制备亚单位疫苗、研发DNA疫苗等来提高对虾抵抗白斑综合征病毒的能力,尽管免疫防治目前在实验室阶段已取得了显著的保护效果,但因其给药方式局限以及成本较高等因素一直没有应用于实际生产中。VP19和VP28是白斑综合征病毒主要的囊膜蛋白,在WSSV感染对虾的过程中起着非常重要的作用。本文从WSSV的基因组学、VP19和VP28的蛋白质结构及其在免疫防治中的应用等方面概述了VP19和VP28的研究进展,包括蛋白亚单位疫苗、DNA疫苗、RNA疫苗以及相关抗体的研究。在总结了不同类型疫苗的保护效果后发现,VP19和VP28的双价疫苗的保护率较高,为今后制定有效的WSSV控制方法提供了参考。
|
| 关 键 词： | 对虾 白斑综合征病毒 VP19 VP28 囊膜蛋白 疫苗 |
| 收稿时间： | 2018/12/5 0:00:00 |
| 修稿时间： | 2019/4/12 0:00:00 |
Review of research progress on white spot syndrome virus (WSSV) envelope protein VP19 and VP28 |
| |
| JIA Rui,ZHU Chan,ZHUANG Minmin,LIAO Shengyu,SHI Dingji and HE Peimin.Review of research progress on white spot syndrome virus (WSSV) envelope protein VP19 and VP28[J].Journal of Fisheries of China,2020,44(5):870-880. |
| |
| Authors: | JIA Rui ZHU Chan ZHUANG Minmin LIAO Shengyu SHI Dingji and HE Peimin |
| |
| Institution: | College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China,College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China,College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China,College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China,College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China;Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China and College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai 201306, China |
| |
| Abstract: | Since the outbreak of white spot syndrome virus (WSSV) in prawn in 1990s, WSSV has attracted extensive attention and research due to its wide outbreak range and high mortality. VP19 and VP28 are main envelope proteins of WSSV, which play important roles in the early stage of the prawn WSSV infection. These studies focused on using envelope proteins VP28 and VP19 to prepare submit vaccines to protect the host, which currently creates significant protective effect. This paper reviews the protein structure of VP28 and VP19 and their role in WSSV invasion, and the immune application of VP19 and VP28 vaccines in WSSV invasion, including protein subunit vaccine, DNA vaccine, RNA vaccine, and corresponding antibody. The protective efficiency of different types of vaccines is summarized, and the protective rate of VP19 + VP28 dual-potency vaccine is relatively high, which provides a reference for formulating effective methods of WSSV control. |
| |
| Keywords: | prawn WSSV VP19 VP28 envelope protein vaccine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《水产学报》浏览原始摘要信息 |
| 点击此处可从《水产学报》下载免费的PDF全文 |
|
