孵化至12月龄大黄鱼免疫器官的发育变化

研究孵化至12月龄大黄鱼的淋巴器官如头肾、胸腺、脾的生长发育和免疫细胞数量的变化,首先应用显微与超微技术研究大黄鱼初孵仔鱼至12月龄免疫器官——头肾、胸腺与脾脏的发育。3日龄仔鱼出现头肾原基,原始造血干细胞最早被发现于头肾,很快分化成不同类型的细胞。4日龄仔鱼出现脾脏原基和胸腺原基。脾脏靠近内脏,含大量窦状隙,有丰富的毛细血管、血细胞与血小板。胸腺是最迟出现的淋巴器官,但发育较快。胸腺位于鳃腔背上角,主要由胸腺细胞(淋巴细胞)和上皮细胞组成,分为外区和内区,二者虽没有明显界限,但容易区分。研究结果还表明,随着年龄和鱼体重量的增长,胸腺、头肾和脾脏的重量均有增长的趋势,脾脏重量与体重的关系要比与年龄的关系更为密切,头肾、胸腺重量与年龄的关系要比与体重的关系更为密切。胸腺、头肾和脾脏的白细胞总数随着年龄的增长不断增加。但每毫克胸腺、头肾和脾脏内白细胞数量与年龄间线性关系不明显。头肾比脾脏淋巴化程度高。在研究中发现,血液内各细胞组成与大黄鱼月龄及季节的变化没有明显的改变。

The development of the lymphoid organs of Larimichthys crocea from hatching to 12 months

The growth of the lymphoid organs,such as head kidney,spleen and thymus was stueied in Larimichthys crocea,from hatching to 12 months of age.A histological and ultrastructural study was performed on the development of the head kidney,thymus and spleen aging from just hatching to the 12 months.Head kidney was first present on the 3rd day after hatching(DAH).Primordial haemopoietic stem cells were first observed in the head kidney and rapidly differentiated into different cellular types.Progenitor spleen was ...